PMID: 11910524Mar 23, 2002Paper

Adrenergic supersensitivity of rabbit choroidal blood vessels after sympathetic denervation

Current Eye Research
P I ChouJ T Chen

Abstract

To demonstrate the phenomenon of adrenergic denervation supersensitivity in rabbit choroidal blood vessels after superior cervical ganglionectomy. Twenty four albino rabbits of both sexes weighing 2-3 kg were randomly separated into two groups. Twelve rabbits received bilateral superior cervical sympathectomy 2 weeks prior to the study (group s). The other 12 rabbits served as controls (group n). Four different concentrations of 0.1 ml phenylephrine, 0.05%, 0.025%, 0.013%, and 0.007% were slowly injected into the vitreous body near the retinal surface in group (n) and (s) rabbits (n = 6 in each group). The choroidal blood flow (PF), blood volume (CMBC), and velocity (V) were measured simultaneously by laser Doppler flowmetry (Perimed, PF 4001). The PF showed similar decreases in group (n) and (s) rabbits after injection of 0.05%, 0.025%, and 0.013% phenylephrine. With 0.007% phenylephrine, the PF remained unchanged in group (n) rabbits, but decreased significantly in group (s) rabbits (p = 0.0007). Velocity decreased similarly in both group (n) and (s) rabbits except for the 0.007% phenylephrine, concentration in which velocity decreased significantly in group s rabbits (p = 0.0001). There was no statistical difference in CMBC ...Continue Reading

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Citations

Apr 21, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·John H K LiuRobert N Weinreb
Jan 27, 2005·Photomedicine and Laser Surgery
Apr 25, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K B SchaalS Dithmar
Feb 4, 2012·Clinical & Experimental Ophthalmology·Kazuyuki HirookaFumio Shiraga
Jul 31, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·David J MillerJohn W Higuchi
Apr 5, 2021·Photodiagnosis and Photodynamic Therapy·Gonul Karatas DurusoyGokhan Demir

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