Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis

American Journal of Physiology. Endocrinology and Metabolism
Gustavo Abreu-VieiraJan Nedergaard

Abstract

Brown adipose tissue (BAT) thermogenesis relies on blood flow to be supplied with nutrients and oxygen and for the distribution of the generated heat to the rest of the body. Therefore, it is fundamental to understand the mechanisms by which blood flow is regulated and its relation to thermogenesis. Here, we present high-resolution laser-Doppler imaging (HR-LDR) as a novel method for noninvasive in vivo measurement of BAT blood flow in mice. Using HR-LDR, we found that norepinephrine stimulation increases BAT blood flow in a dose-dependent manner and that this response is profoundly modulated by environmental temperature acclimation. Surprisingly, we found that mice lacking uncoupling protein 1 (UCP1) have fully preserved BAT blood flow response to norepinephrine despite failing to perform thermogenesis. BAT blood flow was not directly correlated to systemic glycemia, but glucose injections could transiently increase tissue perfusion. Inguinal white adipose tissue, also known as a brite/beige adipose tissue, was also sensitive to cold acclimation and similarly increased blood flow in response to norepinephrine. In conclusion, using a novel noninvasive method to detect BAT perfusion, we demonstrate that adrenergically stimulated...Continue Reading

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Citations

Oct 5, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Denis P Blondin, André C Carpentier
Jul 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S RodovalhoL A Velloso
Mar 10, 2018·Journal of Biophotonics·Sicong HeJianan Y Qu
Nov 18, 2017·Journal of Magnetic Resonance Imaging : JMRI·Alessandro ScottiKejia Cai
Dec 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rosa T BrancaAlex Burant
Sep 21, 2019·Scientific Reports·Crystal L CoolbaughTheodore F Towse
Oct 4, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gabriel RichardMartin Lepage
Aug 28, 2020·Frontiers in Endocrinology·Mingming WuDimitrios C Karampinos
Mar 14, 2018·Contrast Media & Molecular Imaging·Jing YangChongzhao Ran
Jul 20, 2019·Molecular Aspects of Medicine·Ineke H N LuijtenJan Nedergaard
Oct 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Otto MuzikJames G Granneman
Jan 14, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohammed K HankirWiebke K Fenske

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