Adrenoceptors and adaptive mechanisms in the heart during stress

Annals of the New York Academy of Sciences
R C Spadari-Bratfisch, Iraides Nunes dos Santos

Abstract

Several cardiovascular disorders have been related to alterations in beta-adrenoceptor (beta-AR) signaling at or beyond the receptor level. During the stress reaction, the sympathetic-adrenal medullary system and the hypothalamus-pituitary-adrenal cortex axis are activated, causing beta-AR overstimulation and remodeling of the beta(1)/beta(2)/beta(3)-AR ratio in cardiomyocytes. In a model of foot-shock stress, we described decreased beta(1)-AR signaling occurring simultaneously with increased beta(2)-AR signaling, whereas the response to the nonconventional agonist, CGP12177, was not altered. These alterations may play an adaptive role to the increased sympathetic drive to the heart, protecting the cardiac tissue from the cardiotoxic effects mediated by beta(1)-ARs overstimulation without altering cardiac output, since this would be sustained by the beta(2)-AR, which would also protect myocytes from apoptosis. Moreover, the selective enhancement of the beta(2)-AR population might help to diminish the risk of overstimulation since this adrenoceptor subtype couples to both, stimulatory G (Gs) and inhibitory G (Gi) proteins. On the other hand, in the model of neurogenic hypertension, the decrease in beta(1)-AR-mediated response is...Continue Reading

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Citations

May 25, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Wei WangSteven R Houser
Jul 24, 2013·Stress and Health : Journal of the International Society for the Investigation of Stress·Marcela LaukovaJaromir Myslivecek
Dec 17, 2011·Acta Physiologica Hungarica·N SpasojevicSladjana Dronjak
May 2, 2017·Canadian Journal of Physiology and Pharmacology·André Luiz de MouraRegina C Spadari
Oct 25, 2017·Cellular and Molecular Neurobiology·Regina Celia SpadariPaula Frizera Vassalo
Apr 30, 2021·Scientific Reports·Ana Elisa T S de CarvalhoRegina C Spadari

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