Adrenoceptors in Raynaud's disease.

Journal of Cardiovascular Pharmacology
L E LindbladS Bevegård

Abstract

Experiments were designed to study adrenoceptor function in subjects with Raynaud's disease. Sympathetic agonists and antagonists were administered into the finger skin by iontophoresis, and the resulting change in local skin blood flow was evaluated by laser Doppler technique. The effects of norepinephrine (NE, stimulating alpha 1- and alpha 2-adrenoceptors), phenylephrine (stimulating alpha 1-adrenoceptors) were studied in 12 women with Raynaud's disease and in 12 healthy controls. Controls and cases showed a similar consistent vasoconstriction to NE and B-HT 933. All control subjects showed a vasoconstriction to phenylephrine. In contrast, the Raynaud subjects demonstrated a weaker vasoconstriction or even a vasodilation, especially to low concentrations of the drug. After blockade of the alpha 1-adrenoceptors by doxazosin in the controls, phenylephrine mimicked the reaction in Raynaud subjects. beta-Adrenoceptor agonists (isoprenaline and terbutaline) had no effect on finger blood flow in the examined finger skin area in either control or Raynaud subjects. We suggest that Raynaud's disease is characterized by a defect in alpha 1-adrenoceptor function.

Citations

Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M A ChotaniN A Flavahan
Nov 1, 1991·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·D GreensteinR C Kester
Apr 1, 1995·Journal of the American Academy of Nurse Practitioners·H Hodges
Mar 1, 1993·Angiology·T J Cleophas, M G Niemeyer
Aug 16, 2000·Arthritis and Rheumatism·N A FlavahanF M Wigley
Mar 15, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Z LiT L Smith
Jun 1, 1993·The British Journal of Surgery·R A Palmer, J Collin
Jan 1, 1997·La Revue de médecine interne·J J Mourad, P Priollet
Nov 1, 1996·Rheumatic Diseases Clinics of North America·F M Wigley, N A Flavahan

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