PMID: 8606625Jan 1, 1996Paper

Adrenoceptors in SHR: alterations in binding characteristics and intracellular signal transduction pathways

Life Sciences
Y Takata, H Kato

Abstract

There is much data on altered adrenoceptor function in the heart, blood vessel and kidney from spontaneously hypertensive rats (SHR). The enhancement of vascular and renal alpha-adrenoceptor function, i.e. vasoconstriction and retention of water and sodium, may contribute to the development and maintenance of the hypertension, whereas cardiac alpha1-adrenoceptor may be of minor physiological significance. Alpha1-adrenoceptor-mediated signal transduction as a whole is increased in SHR vascular tissues, but the intracellular signaling per receptor in the kidney seems to be decreased despite increased alpha1-adrenoceptor density. On the other hand, cardiac and vascular beta-adrenoceptor responsiveness is attenuated in SHR. Reduced vasorelaxation mediated by beta-adrenoceptors may also contribute to high blood pressure. The impaired cardiovascular beta-adrenoceptor function in SHR does not appear to be necessarily explained by alterations observed at receptor levels. Alterations in signal transduction should be also considered. Limited data on renal beta-adrenoceptor density and its signaling suggest decreased or unaltered cyclic AMP formation per receptor in SHR. We will review alterations in both binding characteristics and each ...Continue Reading

References

May 1, 1976·Circulation Research·W A PettingerD C Harper
Jan 15, 1976·Biochemical Pharmacology·S RamanathanR N Ichord
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Wagner, O E Brodde
Jul 28, 1978·Biochemical and Biophysical Research Communications·C Limas, C J Limas
Oct 12, 1978·Biochimica Et Biophysica Acta·R V Sharma, R C Bhalla
Feb 1, 1979·Biochimica Et Biophysica Acta·C J Limas, C Limas
Jul 1, 1979·The American Journal of Physiology·C R LambertW N Stainsby
Mar 1, 1978·Life Sciences·G KunosL Mucci
May 15, 1978·Biochemical and Biophysical Research Communications·R C BhallaA T Ashley
Mar 1, 1992·Japanese Circulation Journal·F OhsuzuH Nakamura
Dec 1, 1992·Journal of Autonomic Pharmacology·K R BorkowskiH Schneider
Jun 1, 1992·Journal of Cardiovascular Pharmacology·C A JacksonP A Insel
Nov 23, 1992·FEBS Letters·C Thibault, M B Anand-Srivastava
Nov 2, 1992·European Journal of Pharmacology·E BazanR M Rapoport
Mar 3, 1992·European Journal of Pharmacology·P J SilverA L Harris
Sep 1, 1991·Clinical and Experimental Pharmacology & Physiology·S MaieH Ohashi
Jan 1, 1991·American Journal of Hypertension·C K Stanko, D D Smyth
May 15, 1991·Biochemical and Biophysical Research Communications·N MiyataS Otomo

❮ Previous
Next ❯

Citations

May 3, 2013·Pflügers Archiv : European journal of physiology·Martina KlevstigJiri Novotny
Mar 30, 2005·Autonomic Neuroscience : Basic & Clinical·Yassine MallemMarc Gogny
Sep 2, 1998·The Annals of Thoracic Surgery·V MilesiA O Grassi
Feb 18, 2003·Fundamental & Clinical Pharmacology·Jippe C BaltPieter A van Zwieten
Jan 26, 2007·Clinical and Experimental Pharmacology & Physiology·Carla Di VernieroCarlos A Taira
Oct 7, 2004·European Journal of Pharmacology·J Adolfo García-Sáinz, Rafael Villalobos-Molina
Jul 29, 2000·Canadian Journal of Physiology and Pharmacology·E S Werstiuk, R M Lee
Mar 14, 2000·Archives of Medical Research·J A García-SáinzR Villalobos-Molina
Oct 23, 2010·Journal of Agricultural and Food Chemistry·Aleksandra S KristoDorothy J Klimis-Zacas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.