Adrenoceptors in white, brown, and brite adipocytes

British Journal of Pharmacology
Bronwyn A EvansDana S Hutchinson

Abstract

Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte-derived hormones that can control whole-body energy homeostasis. These processes are regulated by the sympathetic nervous system through actions at different adrenoceptor subtypes expressed in adipose tissue depots. In this review, we have highlighted the role of adrenoceptor subtypes in white, brown, and brite adipocytes in both rodents and humans and have included detailed analysis of adrenoceptor expression in human adipose tissue and clonally derived adipocytes. We discuss important considerations when investigating adrenoceptor function in adipose tissue or adipocytes. LINKED ARTICLES: This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.

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Citations

Feb 12, 2019·British Journal of Pharmacology·Ling Yeong ChiaMasaaki Sato
Mar 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Saori MukaidaTore Bengtsson
Dec 24, 2019·The Journal of Clinical Endocrinology and Metabolism·Mette Ji Riis-VestergaardSteen Bønløkke Pedersen
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Aug 20, 2020·Pharmacology Research & Perspectives·Nodi DehvariDana S Hutchinson
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Mar 10, 2021·Journal of Neuroendocrinology·Cait A Beddows, Garron T Dodd
May 1, 2021·Frontiers in Endocrinology·Kasiphak KaikaewJenny A Visser
Jul 1, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hye-Jin LeeDong-Hoon Kim
Dec 29, 2021·Molecular Informatics·Navista Sri Octa UjiantariDaniela Schuster

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