Adrenocortical response in cows after intramuscular injection of long-acting adrenocorticotropic hormone (tetracosactide acetate zinc suspension)

Reproduction in Domestic Animals = Zuchthygiene
N C ThinhT Nakao

Abstract

The objectives of this study were first to show adrenocortical response to a long-acting adrenocorticotropic hormone preparation (tetracosactide acetate zinc suspension) (ACTH-Z) and its effect on adrenocortical function in beef cows (Experiment 1) and second to apply the ACTH-Z challenge in dairy cows based on cortisol concentrations in milk collected at routine milking (Experiment 2). In Experiment 1, four beef cows in luteal phase were challenged with ACTH-Z, and plasma cortisol concentrations were determined for 48 h after the injection at 30-min to 2-h intervals. A rapid ACTH test was conducted 3 days before and 2 h after the completion of ACTH-Z injection for 48 h to investigate the effect on adrenocortical function. Plasma cortisol concentrations increased significantly 30 min after ACTH-Z injection (p < 0.001), and the high cortisol levels were maintained for approximately 10 h after the injection. In Experiment 2, eight dairy cows were subjected to ACTH-Z challenge 1-2 weeks and 4-5 weeks post-partum. Blood and milk samples were taken at morning and afternoon milking. All the cows showed a significant increase in cortisol concentrations in plasma as well as in skim milk 8 h after ACTH-Z injection 1-2 weeks and 4-5 week...Continue Reading

References

Apr 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·F C GwazdauskasM L McGilliard
Oct 1, 1990·Journal of Dairy Science·T Nakao, E Grunert
Oct 1, 1987·Nihon juigaku zasshi. The Japanese journal of veterinary science·K MiyazawaY Ikehiro
Nov 1, 1981·Journal of Dairy Science·S B TermeulenR P Natzke
Jan 1, 1994·Domestic Animal Endocrinology·G A VerkerkL M McLeay
Nov 18, 2000·Animal Reproduction Science·A Y RibaduT Nakao
Mar 8, 2005·The Journal of Reproduction and Development·Chikako Yoshida, Toshihiko Nakao
Jul 1, 2010·Reproduction in Domestic Animals = Zuchthygiene·M YusufT Furuya
Jul 16, 2010·The Journal of Reproduction and Development·Ric R GrummerNoelia Silva-Del-Rio

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Citations

Dec 19, 2012·Journal of Dairy Science·J R DíazC Peris
May 18, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Aleksandra Suszka-ŚwitekRyszard Wiaderkiewicz
Mar 3, 2017·The Journal of Dairy Research·Nataliya PošćićSandy Sgorlon

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