PMID: 11902822Mar 21, 2002Paper

Adrenocorticotrophic hormone exerts marked lipid-lowering effects in simvastatin-treated patients

Journal of Internal Medicine
A HardarsonM Arnadottir

Abstract

Recently, it was reported that treatment with adrenocorticotrophic hormone (ACTH) has a strong lipid-lowering effect in healthy individuals. The mechanism behind this has not been established. The aim of the present investigation was to study the effect of ACTH on the plasma lipoprotein pattern in patients treated with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor. The ACTH treatment was given to 10 patients who were on long-term treatment with simvastatin 40 mg daily. ACTHI-24 was administered at the dose of 1 mg daily for four consecutive days. Blood samples for analyses of lipids, lipoproteins and apolipoproteins were collected before and after treatment. Second baseline was obtained 2 weeks after the end of treatment. The serum concentrations of cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol, apolipoprotein B and lipoprotein(a) fell significantly by 16, 23, 23, 10 and 38%, respectively. The serum apolipoprotein E concentration increased significantly by 39%; the fraction that was not associated with apolipoprotein B increased by 47% whereas the fraction that was did not change significantly. There were no changes in the serum concentrations of high density lipoprotein (HDL) cholesterol a...Continue Reading

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Citations

Mar 9, 2004·Methods : a Companion to Methods in Enzymology·Jeremy MinshullClaes Gustafsson
Jul 15, 2006·Atherosclerosis·Maria SkoogPeter Nilsson-Ehle
Jul 7, 2005·Basic & Clinical Pharmacology & Toxicology·Arnar Thor RafnssonMargret Arnadottir
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·N XuP Nilsson-Ehle

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