Abstract
Recently, it was reported that treatment with adrenocorticotrophic hormone (ACTH) has a strong lipid-lowering effect in healthy individuals. The mechanism behind this has not been established. The aim of the present investigation was to study the effect of ACTH on the plasma lipoprotein pattern in patients treated with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor. The ACTH treatment was given to 10 patients who were on long-term treatment with simvastatin 40 mg daily. ACTHI-24 was administered at the dose of 1 mg daily for four consecutive days. Blood samples for analyses of lipids, lipoproteins and apolipoproteins were collected before and after treatment. Second baseline was obtained 2 weeks after the end of treatment. The serum concentrations of cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol, apolipoprotein B and lipoprotein(a) fell significantly by 16, 23, 23, 10 and 38%, respectively. The serum apolipoprotein E concentration increased significantly by 39%; the fraction that was not associated with apolipoprotein B increased by 47% whereas the fraction that was did not change significantly. There were no changes in the serum concentrations of high density lipoprotein (HDL) cholesterol a...Continue Reading
References
Apr 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·B DanielssonJ Wadstein
Oct 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·P Skinhøj
Nov 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·G C van RhoonH S Reinhold
Feb 1, 1991·Journal of Internal Medicine·A L BergP Nilsson-Ehle
Jun 1, 1990·Journal of Molecular Endocrinology·T ImaiN Matsui
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N YamadaR J Havel
Jan 1, 1997·The American Journal of Cardiology·M H DavidsonJ A Tobert
Jul 1, 1997·Metabolism: Clinical and Experimental·W BartensC Wanner
Jun 5, 1998·JAMA : the Journal of the American Medical Association·J R DownsA M Gotto
Nov 20, 1998·European Heart Journal
Dec 23, 1998·Atherosclerosis·D WoodK Pyörälä
Aug 12, 1999·The New England Journal of Medicine·R H Knopp
Jun 17, 2000·Diabetes Care·E BonoraM Muggeo
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A L Berg, M Arnadottir
Aug 18, 2000·The American Journal of Cardiology·E SteinM Mercuri
Sep 8, 2000·Diabetes Care·B G SeligmanN Clausell
Jul 24, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·M ArnadottirA L Berg
Citations
Mar 9, 2004·Methods : a Companion to Methods in Enzymology·Jeremy MinshullClaes Gustafsson
Jul 15, 2006·Metabolism: Clinical and Experimental·Anna-Lena BergMargret Arnadottir
Jul 15, 2006·Atherosclerosis·Maria SkoogPeter Nilsson-Ehle
Jun 27, 2006·Transplantation Proceedings·X HeN Xu
Jul 7, 2005·Basic & Clinical Pharmacology & Toxicology·Arnar Thor RafnssonMargret Arnadottir
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·N XuP Nilsson-Ehle