Adrenocorticotropin inhibits compensatory adrenal growth after unilateral adrenalectomy

Endocrinology
M F DallmanP M Scholz

Abstract

To determine the interaction between ACTH and compensatory adrenal growth after unilateral adrenalectomy, we have studied the adrenals of young male rats treated with saline, ACTH, dexamethasone, or hypophysectomy and left or sham adrenalectomy (Adx or Sham). ACTH injected at the time of adrenal surgery inhibited the normal increase in [3H]thymidine incorporation into right adrenal DNA at 12 or 18 h (P < 0.05), but increased the RNA content. ACTH treatment (2, 4, or 8 U twice daily) in Shams caused a dose-dependent increase in adrenal weight and the RNA to DNA ratio at 24 h and, subsequently, a dose-dependent increase in adrenal DNA content at 72 h. ACTH treatment of Adx prevented the increase in adrenal DNA content at 24 h (P < 0.05), while increasing the RNA to DNA ratio (P < 0.05) in a dose-dependent manner. Treatment of rats with dexamethasone decreased adrenal weight and RNA content and attenuated the normal response to Adx. ACTH (1 U) at the time of adrenalectomy or sham operation in hypophysectomized rats abolished the normal difference between right adrenal weights in the two groups at 3 days. Adrenal growth occurred in rats hypophysectomized and adrenalectomized 24 h previously compared to Sham controls. These results ...Continue Reading

Citations

May 1, 1982·Pharmacology, Biochemistry, and Behavior·M A AdamsM Hirst
Jul 1, 1984·Pharmacology, Biochemistry, and Behavior·M A Adams, M Hirst
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·S JacksonP J Lowry
Aug 21, 2002·Trends in Endocrinology and Metabolism : TEM·Catherine E Keegan, Gary D Hammer
Jan 1, 1988·Clinical and Experimental Pharmacology & Physiology·S Silberberg, J W Funder
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A M McNicolI D Penman
Jan 1, 1991·Progress in Growth Factor Research·J J Feige, A Baird
May 28, 2003·Microscopy Research and Technique·G P Vinson
Jul 1, 1984·Toxicology and Applied Pharmacology·S Nishiyama, K Nakamura
Jan 1, 1987·Annals of the New York Academy of Sciences·M A HolzwarthN Kleitman
Jan 14, 2016·Journal of Molecular Endocrinology·Andrew B Bicknell
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·W C EngelandB K Levay-Young
Jun 1, 1984·Bioscience Reports·P J Lowry
Feb 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Luke C CareyJames C Rose
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Yvonne M Ulrich-LaiJames P Herman
May 28, 2019·Canadian Journal of Physiology and Pharmacology·Neeshu SarojJosé A Terrón
Jan 1, 1984·Endocrine Research·M F Dallman
Jan 1, 1984·Endocrine Research·P J Hornsby
Jan 18, 2003·Endocrine Research·Andrew B Bicknell
Apr 13, 2018·International Journal of Molecular Sciences·Karol JopekMarcin Rucinski
Feb 1, 1985·The American Journal of Physiology·N Kleitman, M A Holzwarth
Apr 1, 1985·The American Journal of Physiology·R PhillipsJ Funder
May 1, 1986·Biochemical Pharmacology·H P Benton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.