PMID: 11331218May 2, 2001Paper

Adrenomedullin, a new peptide, in patients with insulinoma

European Journal of Endocrinology
C LetiziaE D'Erasmo

Abstract

It has been demonstrated that adrenomedullin, a newly discovered peptide, affects the release of insulin from pancreatic islets cells, suggesting a role in the insulin-regulating system. To investigate whether adrenomedullin secretion is modified in patients with insulin-secreting islet cell tumours. The study was performed in nine patients with surgically treated insulinoma. Circulating adrenomedullin was assayed using a specific radioimmunoassay and its localization and distribution in the tumour were determined by means of immunohistochemistry. Adrenomedullin concentrations were significantly greater in patients with insulinoma (6.6 +/- 3.2 fmol/ml) than in controls (2.1 +/- 1.1 fmol/ml). In six patients monitored before and after surgery, plasma adrenomedullin decreased from 6.3 +/- 2.9 fmol/ml to 3.0 +/- 1.6 fmol/ml. Immunoreactive adrenomedullin was localized exclusively in the tumours cells, whereas stroma, surrounding pancreas parenchyma and major ducts were negative for the peptide. Our findings indicate that circulating adrenomedullin is increased in insulinoma and that this increase is related to the neoplastic phenotype.

Citations

Apr 2, 2003·Regulatory Peptides·E ZudaireA Martínez
Dec 6, 2014·Journal of Translational Medicine·Ignacio M LarráyozAlfredo Martínez
Apr 18, 2006·Pharmacology & Therapeutics·Toshihiko IshimitsuHiroaki Matsuoka
Jun 28, 2016·Domestic Animal Endocrinology·S Martínez-Herrero, A Martínez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.