Adrenomedullin: A potential therapeutic target for retinochoroidal disease

Progress in Retinal and Eye Research
Yasuhiro IesatoYasuo Yanagi

Abstract

Adrenomedullin (AM) is a 52-amino acid peptide with anti-inflammatory, anti-apoptotic, and anti-oxidative properties discovered in a human pheochromocytoma. It is a member of the calcitonin peptide superfamily, and its signal is mediated by calcitonin receptor-like receptor (CLR). CLR interacts with receptor activity-modifying proteins (RAMPs), among which RAMP-2 and RAMP-3 carry CLR from the endoplasmic reticulum to the cellular membrane to confer high affinity for AM. In addition to being implicated in a variety of systemic diseases, AM is a critical contributor to the pathogenesis of retinochoroidal disease. It is robustly upregulated in retinochoroidal disease models of oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularisation (CNV) as well as in human patients with retinochoroidal diseases. In this review, we discuss the most salient recent findings that strongly illustrate the role of AM in retinochoroidal disease. In the OIR model, AM was identified as a key angiogenic mediator of retinal vascularisation, and AM inhibition suppressed only pathological angiogenesis, not physiological angiogenesis. On the contrary, lesion size was larger in AM(+/-) CNV model mice, presumably due to the anti-inflammato...Continue Reading

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Citations

Apr 28, 2017·Drug Development Research·Sayaka NagataKazuo Kitamura
Mar 31, 2018·Molecular Neurobiology·Hilda FerreroMaría J Ramírez
Mar 22, 2019·Journal of Biochemistry·Sayaka NagataKazuo Kitamura
Jul 20, 2021·Progress in Retinal and Eye Research·J BrinksC J F Boon

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