PMID: 11328458May 1, 2001Paper

Adrenomedullin acts in the rat paraventricular nucleus to decrease blood pressure

Journal of Neuroendocrinology
P M Smith, A V Ferguson

Abstract

Adrenomedullin is a recently discovered peptide involved in the control of fluid and electrolyte homeostasis and cardiovascular function through peripheral and central nervous system actions. The present study was undertaken to examine the cardiovascular effects of adrenomedullin microinjection directly into the paraventricular nucleus (PVN). Microinjection of adrenomedullin into the PVN of urethane anaesthetized male Sprague-Dawley rats resulted in site-specific, repeatable decreases in blood pressure. These hypotensive effects were found to be dose related, and were not mediated by activation of calcitonin gene-related peptide receptors. These data suggest that adrenomedullin influences cardiovascular regulation through receptor mediated actions at the PVN of the hypothalamus.

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Citations

Jun 2, 2005·European Journal of Medicinal Chemistry·Miguel JuliánFrank Cuttitta
Apr 2, 2003·Regulatory Peptides·Meghan M TaylorWillis K Samson
Jan 5, 2002·Peptides·M M Taylor, W K Samson
Apr 20, 2002·Journal of Neuroendocrinology·B KisY Ueta
Mar 1, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B Cam-EtozK Ozluk
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Mario A GarcíaAlfredo Martínez
Jun 5, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yong Xu, Teresa L Krukoff
May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adrian Geambasu, Teresa L Krukoff
Jun 28, 2017·Journal of Molecular Neuroscience : MN·Leticia Figueira, Anita Israel
Mar 10, 2018·Frontiers in Immunology·Christopher GevenPeter Pickkers
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew J Follwell, Alastair V Ferguson

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