Adrenomedullin and the integrative physiology of fluid and electrolyte balance

Microscopy Research and Technique
Meghan M Taylor, W K Samson

Abstract

Adrenomedullin (AM) is hypothesized to be a physiologically relevant regulator in fluid and electrolyte homeostasis. AM acts within the central nervous system to inhibit both water and salt intake. The peptide has direct actions in the hypothalamus to decrease vasopressin secretion and in the pituitary gland to inhibit ACTH release. AM decreases production and release of aldosterone from the adrenal glands and acts directly in the kidneys to increase renal blood flow and cause diuresis and natriuresis. Whether or not these complementary actions in brain, pituitary, adrenal gland, and kidney reflect coordinated regulatory mechanisms is currently unknown. Development of molecular tools to determine the physiologic role of endogenous AM will greatly enhance our understanding of AM and its regulation of fluid and electrolyte homeostasis.

References

Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J Antunes-RodriguesW K Samson
Oct 13, 1995·Biochemical and Biophysical Research Communications·H ShojiH Matsuo
Sep 22, 1994·European Journal of Pharmacology·T EbaraH Iwao
Mar 21, 1994·FEBS Letters·K KitamuraT Eto
Jan 1, 1996·Hypertension·M KohnoJ Yoshikawa
Feb 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·R C VariW K Samson
Dec 1, 1995·Journal of Neuroendocrinology·D G Parkes, C N May
Feb 1, 1996·Acta Physiologica Scandinavica·I SzokodiH Ruskoaho
Feb 1, 1997·Endocrinology·W K Samson, T C Murphy
Apr 1, 1997·The Journal of Clinical Endocrinology and Metabolism·P G AndreisG G Nussdorfer
May 1, 1997·Clinical Science·J G LainchburyM G Nicholls
Aug 4, 1999·Brain : a Journal of Neurology·A M Gordon, R Reilmann
Mar 10, 2000·Regulatory Peptides·E MarinoniE V Cosmi

❮ Previous
Next ❯

Citations

Mar 26, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexander S Goldfarb-Rumyantzev, Seth L Alper
Nov 4, 2006·The Journal of Physiology·Esther CristiàMiquel Moretó
Aug 23, 2005·Peptides·Domenico RibattiGastone G Nussdorfer
Oct 11, 2012·Stem Cells International·Sonia Martínez-HerreroAlfredo Martínez
Oct 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maho OgoshiYoshio Takei
Jan 10, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Ana Luísa PiresAdelino F Leite-Moreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved