Adrenomedullin as a pancreatic hormone

Microscopy Research and Technique
J López, N Cuesta

Abstract

Adrenomedullin (AM) is a multiregulatory peptide which is expressed in a wide range of tissues. In the pancreas, AM was first found in mammals, including man, and its colocalization with the pancreatic polypeptide (PP) was established in islet F cells. In addition, three different AM receptors have been characterized in B-cells. AM has been also located in the pancreatic cells of other vertebrate classes. The frequency and distribution of AM cells vary between different animals; they can be found scattered among the exocrine tissue, in the islets, or in ductal epithelia. The colocalization of AM with other hormones presents different patterns, although in birds, as in mammals, it seems to colocalize only with PP. The best-determined pancreatic AM function is the inhibition of insulin secretion in B-cells, which seems to be linked to a recently discovered binding protein, factor H. In relation to this physiological role, clinical data show that AM is raised in some groups of both types I and II diabetic patients and AM might have triggered the disease in a subset of them. On the other hand, AM pancreatic cells are also involved in the response to septic shock by increasing AM circulating levels. A third putative function is the ...Continue Reading

References

Oct 27, 1995·The Journal of Biological Chemistry·S KapasA J Clark
Apr 1, 1995·Histochemistry and Cell Biology·H WashimineT Eto
Jul 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Sep 15, 1993·Biochemical and Biophysical Research Communications·J SakataT Eto
Nov 30, 1994·Biochemical and Biophysical Research Communications·H KanazawaT Takeda
Jun 30, 1994·Biochemical and Biophysical Research Communications·S SugoH Matsuo
Aug 30, 1994·Biochemical and Biophysical Research Communications·T IshimitsuH Matsuo
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Dec 26, 1995·Biochemical and Biophysical Research Communications·S Kapas, A J Clark
May 10, 1996·The Journal of Biological Chemistry·N AiyarY Li
Sep 20, 1996·The Journal of Biological Chemistry·M J MillerF Cuttitta
Jan 13, 1997·Biochemical and Biophysical Research Communications·A SatoD J Autelitano
Sep 1, 1997·Endocrinology·V MartínezY Taché
Nov 26, 1997·Lancet·M HayashiT Fujita
Feb 14, 1998·Journal of Molecular Endocrinology·G D JahnkeF Cuttitta
Mar 10, 1998·Endocrinology·Y IsumiN Minamino
May 16, 1998·Endocrinology·V A Cameron, A M Fleming
May 16, 1998·The Journal of Endocrinology·S KapasJ P Hinson

❮ Previous
Next ❯

Citations

Jun 2, 2005·European Journal of Medicinal Chemistry·Miguel JuliánFrank Cuttitta
Oct 24, 2012·Clinical Endocrinology·Hoi Kin WongBernard M Y Cheung
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Mario A GarcíaAlfredo Martínez
Jun 2, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Natalia CuestaEnrique Zudaire
Oct 31, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naureen JaveedDebabrata Mukhopadhyay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.