Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat

Neuroscience
Julia SerranoA Martínez

Abstract

Changes in the pattern of adrenomedullin expression in the rat cerebral cortex after ischemia-reperfusion were studied by light and electron microscopic immunohistochemistry using a specific antibody against human adrenomedullin (22-52). Animals were subjected to 30 min of oxygen and glucose deprivation in a perfusion model simulating global cerebral ischemia, and the cerebral cortex was studied after 0, 2, 4, 6, 8, 10 or 12 h of reperfusion. Adrenomedullin immunoreactivity was elevated in certain neuronal structures after 6-12 h of reperfusion as compared with controls. Under these conditions, numerous large pyramidal neurons and some small neurons were intensely stained in all cortical layers. The number of immunoreactive pre- and post-synaptic structures increased with the reperfusion time. Neurons immunoreactive for adrenomedullin presented a normal morphology whereas non-immunoreactive neurons were clearly damaged, suggesting a potential cell-specific protective role for adrenomedullin. The number and intensity of immunoreactive endothelial cells were also progressively elevated as the reperfusion time increased. In addition, the perivascular processes of glial cells and/or pericytes followed a similar pattern, suggesting ...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A AlonsoR Llinás
May 28, 1990·Brain Research·G B Richerson, P A Getting
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G J CooperK B Reid
Mar 1, 1972·Journal of Neurochemistry·G KrieglsteinW Urban
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jul 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J RodrigoS Moncada
Apr 1, 1995·Histochemistry and Cell Biology·H WashimineT Eto
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R R WhitesellJ M May
Jul 1, 1993·The European Journal of Neuroscience·M MühlethalerR Llinás
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·X WangG Z Feuerstein
Sep 20, 1996·The Journal of Biological Chemistry·M J MillerF Cuttitta
Jan 1, 1997·Peptides·K TakahashiS Shibahara
Feb 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Jougasaki, J C Burnett
Aug 24, 2000·Molecular Human Reproduction·L L NikitenkoR Bicknell
Mar 27, 2001·Seikagaku. The Journal of Japanese Biochemical Society·K Takahashi
Apr 20, 2001·Journal of Chemical Neuroanatomy·M MuñozA González
Jun 12, 2001·European Journal of Pharmacology·C JuanedaR Quirion

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Citations

Jun 10, 2006·Cellular and Molecular Neurobiology·Masaru HondaMasami Niwa
Apr 2, 2003·Regulatory Peptides·Reiko Udono-FujimoriKazuhiro Takahashi
Apr 2, 2003·Regulatory Peptides·E ZudaireF Cuttitta
May 21, 2004·Nature Reviews. Neuroscience·Frank R Sharp, Myriam Bernaudin
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ana P FernándezAlfredo Martínez
Sep 10, 2009·Antioxidants & Redox Signaling·Sarah K HartenPatrick H Maxwell
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Béla KisYoichi Ueta
Jul 30, 2005·Neuromolecular Medicine·Bronwen MartinStuart Maudsley
Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Armin SchneiderMarkus Schwaninger
Apr 20, 2004·Brain Research. Molecular Brain Research·Armin SchneiderJaroslaw Aronowski
May 24, 2008·Journal of Neurochemistry·Emmanuelle TixierMyriam Bernaudin
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Mario A GarcíaAlfredo Martínez
Sep 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesco M RissoDiego Gazzolo
Jul 6, 2010·Molecular and Cellular Neurosciences·Caterina VeroniCristina Agresti
Mar 5, 2005·Stroke; a Journal of Cerebral Circulation·Kenichiro HanabusaKenji Kangawa
Jan 22, 2020·Neural Regeneration Research·Feng-Jiao LiDong-Mei Wang
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark R GriffithsPhilippe Gasque
Jul 3, 2021·Current Issues in Molecular Biology·Francisco J Julián-VillaverdeAlfredo Martínez
Jul 16, 2014·Pediatrics·Javier Díaz-CastroJulio J Ochoa

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