Adrenomedullin in the adrenal

Microscopy Research and Technique
S Kapas, J P Hinson

Abstract

Adrenomedullin (AM) was originally characterized in extracts of an adrenal medullary tumor. Since this original finding the peptide and its mRNA have also been found in the adrenal cortex, specifically, in the cells of the aldosterone-secreting zona glomerulosa. It is clear that the synthesis of AM is actively regulated in both cortex and medulla. Much research effort has been focused on identifying a role for AM in the adrenal gland. To date, no consistent effect on medullary catecholamine biosynthesis has been demonstrated. In the cortex the actions of AM are controversial and appear to depend on both the tissue preparation used and on the specific receptor population expressed in the individual gland. The results of further studies on the long-term actions of AM on adrenal growth and differentiation are awaited with interest.

References

Aug 1, 1992·Journal of the Autonomic Nervous System·R D O'SheaP M Beart
Apr 1, 1995·Histochemistry and Cell Biology·H WashimineT Eto
Feb 6, 1995·European Journal of Pharmacology·H HeY Abe
Apr 1, 1994·Molecular and Cellular Endocrinology·W E RaineyJ I Mason
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Dec 1, 1995·Journal of Neuroendocrinology·D G Parkes, C N May
Jul 1, 1996·Clinical Science·A M RichardsJ G Lainchbury
Nov 1, 1996·Endocrine Research·S Kapas, J P Hinson
Dec 1, 1996·Endocrine Reviews·T van BiesenR J Lefkowitz
Apr 1, 1997·The Journal of Clinical Endocrinology and Metabolism·P G AndreisG G Nussdorfer
May 16, 1998·Endocrinology·V A Cameron, A M Fleming
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
May 16, 1998·The Journal of Endocrinology·S KapasJ P Hinson
Jun 30, 2001·The Journal of Endocrinology·L M ThomsonJ P Hinson

❮ Previous
Next ❯

Citations

Mar 23, 2011·International Journal of Hypertension·Andreas Moraitis, Constantine Stratakis
Sep 14, 2012·The Journal of International Medical Research·M PeckováM Horackova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.