Adrenomedullin is a novel marker of tumor progression in neuroendocrine carcinomas

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M E PavelD Schuppan

Abstract

Adrenomedullin is a multi-functional polypeptide hormone. Its involvement in angiogenesis and vasodilator action support the hypothesis that adrenomedullin may be a secretory product of neuroendocrine tumors and contribute to tumor progression. Plasma levels of adrenomedullin were measured by radioimmunoassay in 46 patients with neuroendocrine carcinomas of the gastroenteropancreatic and bronchial system. Tissue expression of adrenomedullin was studied using monoclonal antibodies on pretreated paraffin embedded tissues in a group of 31 patients. Adrenomedullin plasma levels were significantly elevated in patients compared to healthy age-matched controls (p < 0.001). The highest plasma levels were found in patients with neuroendocrine carcinomas of bronchial, midgut and unknown origin. Patients with progressive disease had higher plasma levels than patients with stable disease (p < 0.001). Of the examined tumor samples, 55 % showed cytoplasmic staining for adrenomedullin > 5 % of the total tumor area. Plasma levels and tissue expression of adrenomedullin did not correlate with functional activity of the tumors or presence of the carcinoid syndrome, but did with tumor progression (p < 0.001 and p < 0.014). In conclusion, plasma a...Continue Reading

Citations

Apr 11, 2008·Journal of Endocrinological Investigation·P FerollaA Colao
Dec 6, 2014·Journal of Translational Medicine·Ignacio M LarráyozAlfredo Martínez
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Wouter W de Herder
Jan 17, 2012·Proteomics·Miroslava Stastna, Jennifer E Van Eyk
Jul 7, 2015·European Journal of Pharmacology·Johji Kato, Kazuo Kitamura
Sep 18, 2010·Expert Opinion on Therapeutic Targets·Jean-Laurent DevilleLaurent Daniel
Aug 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Trent R HummelNancy Ratner

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