Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo

The American Journal of Physiology
J CornishI R Reid

Abstract

Adrenomedullin is a 52-amino acid vasodilator peptide produced in many tissues, including bone. It has 20% sequence identity with amylin, a regulator of osteoblast growth, and circulates in picomolar concentrations. The present study assesses whether adrenomedullin also acts on osteoblasts. At concentrations of 10(-12) M and greater, adrenomedullin produced a dose-dependent increase in cell number and [3H]thymidine incorporation in cultures of fetal rat osteoblasts. This effect was also seen with adrenomedullin-(15-52), -(22-52), and -(27-52), but adrenomedullin-(40-52) was inactive. These effects were lost in the presence of amylin blockers, suggesting they were mediated by the amylin receptor. Adrenomedullin also increased [3H]thymidine incorporation into cultured neonatal mouse calvaria but, unlike amylin, did not reduce bone resorption in this model. Adrenomedullin stimulated phenylalanine incorporation into both isolated osteoblasts and calvaria. When injected daily for 5 days over the calvariae of adult mice, it increased indexes of bone formation two- to threefold (P < 0.0001) and increased mineralized bone area by 14% (P = 0.004). It is concluded that adrenomedullin regulates osteoblast function and that it increases bo...Continue Reading

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Citations

Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J CornishI R Reid
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ian R ReidPaul A Baldock
Jan 16, 2013·The Bulletin of Tokyo Dental College·Masakazu TazakiKenji Sueishi
Dec 13, 2018·Physiological Reviews·Dorit NaotJillian Cornish
Aug 3, 2010·Rheumatology International·Pooneh Salari SharifBagher Larijani
Sep 24, 2020·International Journal of Endocrinology·Jingbo XieQingshan Sun
Nov 8, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Bronský, R Průsa
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·J CornishI R Reid

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