PMID: 9551873Apr 29, 1998Paper

Adrenomedullin levels are high in primary aldosteronism due to adenoma and decline after surgical cure

Blood Pressure
C LetiziaA De Ciocchis

Abstract

The aim of the study was to evaluate the possible changes in plasma adrenomedullin (AM) levels in patients with primary aldosteronism before and after surgical resection. The study included 13 patients affected by aldosterone-producing adenoma (9 women, 4 men; mean age 36.2+/-14.2 years) and 20 healthy control subjects (7 women, 13 M; mean age 31.8+/-12.4 years). Unilateral adrenalectomy was performed in all patients and adrenal mass consisted of a benign adrenal cortical adenoma. The mean plasma AM concentrations in patients with primary aldosteronism (36.2+/-19.3 pg/ml) were significantly (p < 0.0001) higher than those of normal subjects (13.2+/-6.2 pg/ml). In these patients the plasma AM levels significantly (p < 0.0001) reduced after surgical removal of the tumours (14.9+/-7.6 pg/ml). In all patients with aldosterone-producing adenoma, tumour diameter correlated with the plasma AM concentrations (r=0.631; p < 0.021). In conclusion, the present investigation shows that in primary aldosteronism due to adrenal adenoma plasma AM levels are higher at the moment of diagnosis and decline after successful adrenal operation.

References

Jun 30, 1994·Biochemical and Biophysical Research Communications·S SugoH Matsuo
Mar 21, 1994·FEBS Letters·K KitamuraT Eto
Sep 14, 1993·European Journal of Pharmacology·Y IshiyamaT Eto
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Jan 1, 1996·Hypertension·M KohnoJ Yoshikawa
Oct 1, 1995·American Journal of Hypertension·K KatoT Eto
Oct 1, 1996·Clinical and Experimental Hypertension : CHE·C LetiziaD Scavo
Feb 1, 1997·Lancet·R Di IorioE V Cosmi
Jul 1, 1995·Journal of Endocrinological Investigation·R D Gordon

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Citations

Sep 14, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Claudio LetiziaEmilio D' Erasmo
Feb 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshihiro KitaKazuo Kitamura
May 9, 2012·Clinical and Experimental Hypertension : CHE·Sarah VogtHolger S Willenberg
Apr 27, 2000·Endocrine Reviews·J P HinsonD M Smith
Dec 6, 2014·Journal of Translational Medicine·Ignacio M LarráyozAlfredo Martínez

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