Adrenomedullin relaxes rat uterine artery: mechanisms and influence of pregnancy and estradiol.

Endocrinology
Gracious R RossChandra Yallampalli

Abstract

Uterine arteries play a major role in regulating uteroplacental blood flow. Failure to maintain blood flow to the uteroplacental compartment during pregnancy often results in intrauterine growth retardation. Immunohistochemical staining of adrenomedullin (AM), an endogenous vasoactive peptide, in uterine artery was intense in pregnant compared to nonpregnant rats, but it is not known whether AM directly relaxes uterine artery or not. In this study, we elucidated the mechanisms of uterine artery relaxation by AM and its regulation by pregnancy and female sex steroids. AM was able to relax uterine artery, and this relaxation was influenced positively by pregnancy and estradiol as evidenced by the increased pD(2) and E(max) values of AM. Both pregnancy and estradiol treatment to ovariectomized rats amplified RAMP(3) expression in uterine arteries while progesterone had no effect. AM-induced uterine artery relaxation is predominantly endothelium-dependent. The AM receptor antagonist CGRP(8-37) is more potent than AM(22-52) in inhibiting the AM relaxation, indicating the involvement of AM(2) receptor subtype. Moreover, AM uses the classical nitric oxide-cyclic guanosine monophosphate pathway along with K(Ca) channels to mediate the ...Continue Reading

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Citations

Feb 10, 2012·International Journal of Hypertension·Roxana N PeroniEdda Adler-Graschinsky
Nov 13, 2012·Drug Discovery Today. Disease Models·Jt McGuane, Kp Conrad
Mar 20, 2012·Trends in Endocrinology and Metabolism : TEM·Patricia M Lenhart, Kathleen M Caron
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May 21, 2016·Frontiers in Physiology·Manuel MaliqueoNicolás Crisosto
Feb 1, 2017·Journal of Cardiovascular Pharmacology·Jude S MortonSandra T Davidge
Aug 9, 2020·Biology of Reproduction·Chellakkan S BlessonChandra Yallampalli
Mar 22, 2020·International Journal of Molecular Sciences·Kathirvel Gopalakrishnan, Sathish Kumar
Mar 10, 2018·Frontiers in Immunology·Christopher GevenPeter Pickkers
Oct 30, 2015·Biology of Reproduction·Yuanlin DongChandrasekhar Yallampalli
Apr 12, 2020·International Journal of Molecular Sciences·Maurizio Mandalà
Aug 28, 2021·International Journal of Molecular Sciences·Xiangqun Hu, Lubo Zhang

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