PMID: 8606617Jan 1, 1996Paper

Adrenomedullin stimulates calcium efflux from adrenal chromaffin cells in culture: possible involvement of an Na+/Ca2+ exchange mechanism

Life Sciences
H HouchiM Oka

Abstract

The effect of adrenomedullin, a hypotensive peptide, on Ca2+ efflux from cultured bovine adrenal chromaffin cells was examined. Adrenomedullin stimulated the efflux of 45Ca2+ from the cells in a concentration-dependent manner (10(-7)M - 3x10(-6)M). Adrenomedullin did not increase the intracellular free Ca2+ ([Ca2+]i) level and catecholamine secretion. The adrenomedullin-stimulated 45Ca2+ efflux was not inhibited by incubation with Ca2+-free medium, but was inhibited by incubation with Na+-free medium. These results indicate that adrenomedullin stimulates extracellular Na+-dependent 45Ca2+ efflux from cultured bovine adrenal chromaffin cells, probably through its stimulatory effect on membrane Na+/Ca2+ exchange.

References

Jul 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Sep 15, 1993·Biochemical and Biophysical Research Communications·J SakataT Eto
Apr 15, 1994·Biochemical and Biophysical Research Communications·Y IshizakaT Eto
Sep 14, 1993·European Journal of Pharmacology·Y IshiyamaT Eto
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto

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