PMID: 11927388Apr 3, 2002Paper

Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude

The Journal of Endocrinology
G F GonzalesA Villena

Abstract

The present study aimed to determine adrenopause or reduction of serum adrenal androgens with age at high altitude and at sea level. It was a cross-sectional study performed in 210 women resident at high altitude (4340 m) and 123 women living in Lima (150 m), aged 20-70 years. Fasting early morning blood samples were obtained. Serum dehydroepiandrosterone (DHEA), DHEA sulphate (DHEAS), androstenedione, testosterone and estradiol were measured by radioimmunoassay. Serum testosterone concentrations were greater in women living at high altitude than in those resident at sea level. Serum concentrations of DHEA, DHEAS and androstenedione were lower in women living at high altitude than in those living at sea level. The DHEAS/DHEA ratio was significantly greater, and the androstenedione/testosterone ratio was lower in samples from women living at high altitude. Among women older than 50 years of age, a greater decline in serum concentrations of DHEA was observed in those living at high altitude than in those living at sea level. Among women 60-70 years of age, serum concentrations of DHEA at high altitude were 46.9% of those in women of the same age living at sea level. Decay of DHEAS at sea level and at high altitude occurred from t...Continue Reading

Citations

Dec 4, 2003·Current Opinion in Pharmacology·Emanuela Binello, Catherine M Gordon
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Gustavo F GonzalesCynthia Gonzales-Castañeda
Jul 12, 2003·High Altitude Medicine & Biology·Virginia J Vitzthum, Andrea S Wiley
Sep 14, 2007·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Benjamin C CampbellKenneth Campbell
Nov 6, 2009·American Journal of Physical Anthropology·Virginia J Vitzthum
Feb 6, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Virginia J Vitzthum
Mar 24, 2016·Geriatrics & Gerontology International·Ryota SakamotoKozo Matsubayashi

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