Adriamycin and daunomycin induce interstrand DNA crosslinks in Hela S3 Cells

Biochemical and Biophysical Research Communications
J Konopa

Abstract

By using a new mild procedure for detecting DNA crosslinks it has been shown that adriamycin and daunomycin are able to form interstrand DNA crosslinks in HeLa cells. This effect seems to be preceded by transformation of the parent antibiotics in the cell to active forms. In addition, interstrand DNA crosslinks formed by adriamycin and daunomycin were found to be temperature- and alkali-labile.

References

Feb 1, 1977·Nucleic Acids Research·R B Sheridan, P C Huang

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Citations

Aug 3, 1993·Biochemical Pharmacology·A Skladanowski, J Konopa
Jun 15, 1994·Biochemical Pharmacology·A Skladanowski, J Konopa
Dec 22, 1995·Chemico-biological Interactions·M ColucciaG Natile
May 1, 1995·General Pharmacology·M Gniazdowski, L Szmigiero
Oct 1, 1993·Mutation Research·R D AndersonW D Sedwick
Jan 11, 1995·Nucleic Acids Research·A van RosmalenD R Phillips
Jul 11, 1995·Nucleic Acids Research·S M Cutts, D R Phillips
Jul 23, 2005·IUBMB Life·Suzanne M CuttsDon R Phillips
Jul 1, 1999·Molecular Pharmacology·K NeplechováV Brabec
Sep 1, 1997·Molecular Pharmacology·R ZaludováV Brabec
Feb 18, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumiyasu EndoHideyuki Akaza
Sep 1, 1992·Toxicology and Applied Pharmacology·D M YourteeR E Smith

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