PMID: 6159961Dec 1, 1980Paper

Adriamycin, bleomycin, DIC, CCNU, and prednisone (ABDIC) chemotherapy in MOPP-resistant Hodgkin's disease

Cancer
R W RodgersC C Shullenberger

Abstract

ABDIC was administered to 32 patients with MOPP-resistant Hodgkin's disease. Three were considered nonevaluable because of early death. All patients had received MOPP (medium of eight cycles), and five had also received other chemotherapy. Major radiotherapy had been used in 18 of the 29. Complete remission (CR) occurred in 10 of 29 (34.5%), partial remissions (PR) in 14 (48.2%), and no remissions (NR) in five (17.2%). Median survival and relapse-free survival for CR patients exceeded 28 months. Two relapsed at 8 and 18 months; one died at 9 1/2 months, and the other is disease-free with other treatment at 35 months. Seven of the remaining eight patients are alive without disease (10-35 months); 4 are on maintenance therapy, and the other died from an infection and eosinophilic granuloma of lung without evidence of recurrent Hodgkin's disease. Median survival of PR patients was eight months. One patient with Hodgkin's disease involving the liver is alive at 36 months with further therapy. Median survival of NR patients is 2.5 months, and all died within seven months. Survival of CR patients is greater than PR and NR patients (P = 0.002), and that of PR is greater than NR (P = 0.01). Four of the 29 patients had nodal relapse, an...Continue Reading

References

Dec 20, 1975·Lancet·J M Goldman, A A Dawson
Jan 3, 1977·JAMA : the Journal of the American Medical Association·V VinciguerraR T Silver
Feb 1, 1974·Annals of Internal Medicine·R H Blum, S K Carter
Jan 1, 1973·Revue Roumaine De Médecine Interne·M GociuS Berceanu
Dec 1, 1970·Annals of Internal Medicine·V T DevitaP P Carbone

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Citations

Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anne B Neef, Nathan W Luedtke
Sep 1, 1987·The American Journal of Medicine·A C BuzaidT P Miller
Mar 1, 1982·Cancer Treatment Reviews·G Bonadonna, A Santoro
Jun 15, 1983·Cancer·L M Fuller, F B Hagemeister
Aug 1, 1983·Australian and New Zealand Journal of Medicine·I N OlverJ Matthews

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