PMID: 6404846Jan 1, 1983Paper

Adriamycin induced immunomodulation: dependence upon time of administration

International Journal of Immunopharmacology
M J EhrkeE Mihich

Abstract

The immunomodulating capabilities of the anti-neoplastic agent, Adriamycin, were investigated. The day of Adriamycin administration to mice was varied from -15 to -1, day 0 being when mice were either immunized or sacrificed and their spleen cells sensitized in culture. Humoral and cellular immune responses against allogeneic or xenogeneic cellular antigens in mice and in culture, as well as phagocytic and ADCC activities were evaluated using spleen cell populations. The cellular responses and phagocytic activities were affected in a cyclical manner with time after Adriamycin's administration. Peaks of increased activity were seen subsequent to day -5 and day -11, administration and low activities following day -1, -3 and day -7, -9 administration. The humoral responses were not affected in a biphasic manner but single peaks of increased activity were seen which corresponded to the times of low cellular cytolytic and phagocytic activities. The ADCC was independent of time of Adriamycin administration. The significance of these findings to the design of therapeutic protocols is discussed.

References

May 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MantovaniF Spreafico
Sep 1, 1966·The Journal of Experimental Medicine·D Chanmougan, R S Schwartz
Jan 1, 1980·Advances in Enzyme Regulation·S A CohenE Mihich

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Citations

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·D L MaccubbinM J Ehrke
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·P Lefrancier
Jan 1, 1984·International Journal of Immunopharmacology·K RyoyamaE Mihich
Jul 16, 2003·International Immunopharmacology·M Jane Ehrke
Sep 30, 2010·Nature Reviews. Clinical Oncology·Robert C Bast, Maurie Markman
Jan 1, 1991·International Journal of Immunopharmacology·A BalsariM Ghione

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