ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation.

Antimicrobial Agents and Chemotherapy
Emmanuel González-OrtegaJosé A Esté

Abstract

We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was cross-resistant to the polyanion dextran sulfate, and recombination of gp120 recovered only the ADS-J1-resistant phenotype. In summary, ADS-J1 blocks an early step of virus entry that appears to be driven by gp120 alone.

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Citations

Dec 17, 2011·Nature Reviews. Drug Discovery·Christopher D FjellGisbert Schneider
Jun 15, 2012·Journal of Virology·Marc PermanyerJosé A Esté
Mar 8, 2011·Trends in Microbiology·Michael Caffrey
Oct 23, 2010·Trends in Microbiology·Marc PermanyerJosé A Esté
Jun 10, 2015·Antimicrobial Agents and Chemotherapy·Tianrong XunShuwen Liu
Mar 17, 2019·The Biochemical Journal·Jinqing LiSuiyi Tan
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ester BallanaJosé A Esté
Jul 2, 2021·Annual Review of Virology·Han-Yuan Liu, Priscilla L Yang

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