Adsorbent phases with nanomaterials for in-tube solid-phase microextraction coupled on-line to liquid nanochromatography

Journal of Chromatography. a
Rodrigo A González-FuenzalidaP Campíns-Falcó

Abstract

Following the present trends in miniaturization, a methodology that combines on-line In-Tube Solid-Phase Microextraction (IT-SPME) with Liquid Nanochromatography (nano-LC) and UV-vis diode array detection (DAD) was developed. This coupling was achieved by using two interconnected valves (i.e. conventional and micro-automatic valves) in the system of injection. As for IT-SPME, different materials, containing in some cases nanostructures or nanoparticles and in other cases polymeric adsorbent phases immobilized on capillary columns, were tested in order to improve extraction efficiencies of organic compounds; diclofenac was selected as the target analyte. Additionally, the transfer time of the sample between the two injection valves, as well as the lengths and the internal diameters of the capillary columns, was optimized. Under the selected conditions, the resulting IT-SPME-nano-LC-DAD method showed great potential to become a powerful analytical tool as it was successfully applied to the determination of diclofenac in pharmaceutical and water samples. For comparison purposes, IT-SPME coupled to Capillary Liquid Chromatography (Cap-LC) was used. The extraction yield of diclofenac reached near 80%, a high value for techniques tha...Continue Reading

References

Jul 11, 2002·Journal of the American Chemical Society·Shouheng Sun, Hao Zeng
Sep 21, 2010·Analytical and Bioanalytical Chemistry·Li XuYu-Qi Feng
Aug 7, 2012·Analytical Chemistry·Y Moliner-MartínezP Campíns-Falcó
Aug 25, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ming-Luan ChenYu-Qi Feng

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Citations

Apr 21, 2018·Electrophoresis·Edvaldo V Soares MacielFernando Mauro Lanças
Feb 23, 2018·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ana L De ToffoliFernando M Lanças
Oct 6, 2018·Journal of Separation Science·Edvaldo Vasconcelos Soares MacielFernando Mauro Lanças
May 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia Manousi, George A Zachariadis
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Henry Daniel Ponce-RodríguezPilar Campíns-Falcó
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia ManousiConstantinos K Zacharis
Dec 29, 2020·Journal of Chromatography. a·Hiroyuki Kataoka
Dec 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiong JiangMin Sun
Feb 3, 2021·Journal of Separation Science·Caroline Fernandes GreccoMaria Eugênia Costa Queiroz
Apr 18, 2021·Analytica Chimica Acta·Francisco Pena-PereiraElefteria Psillakis

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