Adsorption and release kinetics of growth factors on barrier membranes for guided tissue/bone regeneration: A systematic review

Archives of Oral Biology
Jordi Caballé-SerranoRichard J Miron

Abstract

Guided bone / tissue regeneration (GBR/GTR) procedures are necessary to improve conditions for implant placement. These techniques in turn can be enhanced by using growth factors (GFs) such as bone morphogenetic protein (BMP-2) and platelet-derived growth factor (PDGF) to accelerate regeneration. The aim of the present systematic review was to evaluate the GF loading and release kinetics of barrier membranes. A total of 138 articles were screened in PubMed databases, and 31 meeting the inclusion criteria were included in the present systematic review. All the articles evaluated bio-resorbable membranes, especially collagen or polymer-based membranes. In most studies, the retention and release kinetics of osteogenic GFs such as BMP-2 and PDGF were widely investigated. Growth factors were incorporated to the membranes by soaking and incubating the membranes in GF solution, followed by lyophilization, or mixing in the polymers before evaporation. Adsorption onto the membranes depended upon the membrane materials and additional reagents such as heparin, cross-linkers and GF concentration. Interestingly, most studies showed two phases of GF release from the membranes: a first phase comprising a burst release (about 1 day), followed ...Continue Reading

Citations

Dec 14, 2019·Journal of Materials Science. Materials in Medicine·Menemşe GümüşderelioğluArlin S Kiremitçi
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zoi TerzopoulouDimitrios Bikiaris
Nov 3, 2020·Frontiers in Endocrinology·Jin LiYang Xia
Jan 29, 2021·BioMed Research International·Luca FiorilloMarco Cicciù
Feb 4, 2021·Advanced Functional Materials·Charlotte GarotCatherine Picart
Aug 24, 2021·Frontiers in Bioengineering and Biotechnology·Jessica M LatimerWilliam V Giannobile
Sep 29, 2021·Chemical Biology & Drug Design·Sadaf Ul HassanAysha Mohyuddin

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