Adsorption of Myoglobin and Corona Formation on Silica Nanoparticles.

Langmuir : the ACS Journal of Surfaces and Colloids
Jin Gyun LeeBhuvnesh Bharti

Abstract

The adsorption of proteins from aqueous medium leads to the formation of protein corona on nanoparticles. The formation of protein corona is governed by a complex interplay of protein-particle and protein-protein interactions, such as electrostatics, van der Waals, hydrophobic, hydrogen bonding, and solvation. The experimental parameters influencing these interactions, and thus governing the protein corona formation on nanoparticles, are currently poorly understood. This lack of understanding is due to the complexity in the surface charge distribution and anisotropic shape of the protein molecules. Here, we investigate the effect of pH and salinity on the characteristics of corona formed by myoglobin on silica nanoparticles. We experimentally measure and theoretically model the adsorption isotherms of myoglobin binding to silica nanoparticles. By combining adsorption studies with surface electrostatic mapping of myoglobin, we demonstrate that a monolayered hard corona is formed in low salinity dispersions, which transforms into a multilayered hard + soft corona upon the addition of salt. We attribute the observed changes in protein adsorption behavior with increasing pH and salinity to the change in electrostatic interactions a...Continue Reading

References

Aug 30, 1983·Biochemistry·E BismutoG Irace
Oct 1, 1980·Biophysical Journal·H Frauenfelder, G A Petsko
Aug 16, 1994·Biochemistry·Y Konishi, R Feng
Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
Jun 25, 2004·Nucleic Acids Research·Todd J DolinskyNathan A Baker
Sep 2, 2004·The Journal of Experimental Biology·George A Ordway, Daniel J Garry
Oct 19, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Maria M Santore, Christian F Wertz
Jan 31, 2006·Biophysical Journal·Stina LindmanSara Linse
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tommy CedervallSara Linse
Jun 25, 2008·Nature Materials·Younjin MinJacob Israelachvili
Feb 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Rune A HartvigHenrik Jensen
Jul 7, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Bhuvnesh BhartiGerhard H Findenegg
May 29, 2012·ACS Nano·Gregory Von WhiteChristopher L Kitchens
Aug 14, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Satoshi NagaoShun Hirota
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Apr 9, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·James O HardinValeria T Milam
Sep 24, 2013·Nature Nanotechnology·Stefan TenzerRoland H Stauber
Oct 3, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Stéphanie DevineauJean Philippe Renault
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alexandar L Hansen, Lewis E Kay
Mar 31, 2015·Nature Nanotechnology·Philip M KellyKenneth A Dawson
Jul 15, 2015·Colloids and Surfaces. B, Biointerfaces·Mikael Lund
Sep 16, 2015·ACS Applied Materials & Interfaces·Alden M ClemmentsChristopher C Landry
Feb 8, 2011·Journal of Chemical Theory and Computation·Mats H M OlssonJan H Jensen
Jul 12, 2011·Journal of Chemical Theory and Computation·Chresten R SøndergaardJan H Jensen
Dec 1, 2015·Colloid and Polymer Science·Jens MeissnerGerhard H Findenegg
Nov 16, 2016·Nature Communications·Maria Cristina Lo GiudiceKenneth A Dawson
Jan 13, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Indresh YadavJoachim Kohlbrecher
Apr 20, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Sugam KumarJoachim Kohlbrecher
Nov 20, 2018·ACS Applied Materials & Interfaces·Jin Gyun LeeBhuvnesh Bharti
Nov 24, 2018·Soft Matter·Jens MeissnerBhuvnesh Bharti
Jun 30, 2019·Advanced Materials·C Wyatt ShieldsSamir Mitragotri
Jul 2, 2019·Journal of the Science of Food and Agriculture·Sara RagucciAntimo Di Maro
Jul 25, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Laurent MarichalJean Philippe Renault
Jan 7, 2020·ACS Sensors·Khashayar R BajgiranAdam T Melvin
Mar 24, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yingzhen MaBhuvnesh Bharti
Mar 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Won Min ParkJulie A Champion

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Environmental Research and Public Health·Monika WasilewskaZbigniew Adamczyk
Jun 8, 2021·Current Opinion in Colloid & Interface Science·Zbigniew AdamczykJakub Barbasz
Jun 22, 2021·Biomaterials Science·Arjaree JobdeedamrongDaniel Crespy
Sep 7, 2021·Frontiers in Physiology·Joanna Xiuzhu Xu, Nicholas C Fitzkee

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic
transmission electron microscopy
X-ray

Software Mentioned

PROPKA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Biological Macromolecules
Rakesh Kumar MishraRehan Khan
Giornale italiano di cardiologia : organo ufficiale della Federazione italiana di cardiologia : organo ufficiale della Società italiana di chirurgia cardiaca
Marco MetraAldo P Maggioni
Mathematical Biosciences
Vladimir P Zhdanov, Nam-Joon Cho
© 2021 Meta ULC. All rights reserved