PMID: 9549614Apr 29, 1998Paper

Adsorption of proteins onto poly(ether urethane) with a phosphorylcholine moiety and influence of preadsorbed phospholipid

Journal of Biomedical Materials Research
A P van der HeidenL H Koole

Abstract

In a previous report we demonstrated that the blood compatibility of poly(ether urethane) (PEU) was improved by grafting phosphorylcholine (PC) groups on the surface. The improved blood compatibility was indicated by decreased platelet adsorption/activation and reduced thrombin formation at the polymer surface in experiments in which the surfaces were contacted with platelet-rich plasma in vitro. In the present study, we investigated the effect of grafted PC groups at a PEU surface on protein and phospholipid adsorption. Adsorption of human fibrinogen (Fg), human serum albumin (Alb), human high-molecular-weight kininogen (HMWK), and dioleoyl phosphatidylcholine (DOPC) vesicles was measured by ellipsometry. For this purpose, thin PEU films were cast on silicon wafers. The polymer film was photochemically modified with a PC-containing aryl azide. The presence of PC groups on the polymer surface was demonstrated by ESCA (Electron Spectroscopy for Chemical Analysis). The hydrophilicity of the polymer surface increased by the surface modification, as indicated by a decrease of the contact angle from 59 degrees before to 43 degrees after modification. Our data show that the presence of PC groups has little effect on the adsorption of...Continue Reading

References

Jan 1, 1991·Journal of Biomaterials Science. Polymer Edition·T UedaN Nakabayashi
Nov 1, 1991·Journal of Biomedical Materials Research·K IshiharaJ M Anderson
Jan 1, 1987·Annals of the New York Academy of Sciences·R E Baier
Jan 1, 1987·Annals of the New York Academy of Sciences·A S Hoffman
May 7, 1982·Biochimica Et Biophysica Acta·O AlbrechtD Chapman
Aug 1, 1995·Journal of Biomedical Materials Research·Y B Aldenhoff, L H Koole
Oct 1, 1993·Journal of Biomedical Materials Research·K IshiharaN Nakabayashi

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Citations

Feb 22, 2005·Analytical and Bioanalytical Chemistry·Yasuhiko Iwasaki, Kazuhiko Ishihara
Aug 1, 2000·Colloids and Surfaces. B, Biointerfaces·A L Lewis
Oct 6, 2001·Journal of Biomaterials Science. Polymer Edition·L BacákováV Hnatowicz
Jan 15, 2005·Journal of Biomaterials Science. Polymer Edition·Yong-Kuan GongFrancoise M Winnik
Dec 25, 2008·Journal of Biomaterials Science. Polymer Edition·Lisa M ChowLyndon Jones
May 19, 2010·International Journal of Molecular Sciences·Jun CaoXianglin Luo
Mar 30, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Victoria B TranC J Radke
May 12, 2015·Journal of medical and biological engineering·Hongbin Zhang, Mu Chiao
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad Irfan, Ani Idris
Jun 20, 2017·Journal of Oleo Science·Mutsuo Tanaka, Shigeru Kurosawa
Apr 12, 2012·Journal of Biomedical Materials Research. Part a·Anand Khandwekar, Cho K Rho
Feb 13, 2007·Small·Prashanth AsuriJonathan S Dordick
Oct 7, 2010·Advanced Materials·Chandramouleeswaran SubramaniVincent M Rotello
Jun 5, 2021·Journal of Biomaterials Science. Polymer Edition·Mahdi Aghajani, Fariba Esmaeili
Aug 10, 2021·Materials Today·Gauri BhaveJacob T Robinson

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