ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne

Dermato-endocrinology
Marco A D RochaEdieia Bagatin

Abstract

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and present some clinical differences compared to adolescent acne. Local glandular metabolism turns some weak hormonal precursors into more active substances that increase the production of sebum, leaving these areas more prone to an increasing the colonization by Propionibacterium acnes (P. acnes). Our objective was to evaluate the usefulness of an androgenic metabolite as an adult female acne biomarker. The study population consisted of 38 adult women with acne without any features of hyperandrogenism and a control group. They were recruited from the clinic of Dermatology Hospital Division of São Paulo, Federal University of São Paulo from January 2012 to September 2014. After the first hormonal dosages, patients with acne were randomized into two different groups: one receiving a combined oral contraceptive (COC) containing 0,02 mg of ethinylestradiol and 3 mg drospirenone in a regimen of 24 days of medication, and the other group was treated with a topical gel containing 15% azelaic acid (AA), twice daily, both for s...Continue Reading

References

Nov 1, 1988·The British Journal of Dermatology·D StamatiadisI Mowszowicz
Nov 1, 1993·Clinical Endocrinology·V ToscanoF Sciarra
Aug 14, 1998·Journal of the American Academy of Dermatology·G M White
Jan 20, 1999·The British Journal of Dermatology·M KilkennyR Marks
Sep 18, 1999·Archives of Dermatology·D ThiboutotD Lookingbill
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·F PoliM Verschoore
Oct 26, 2002·Journal of Endocrinological Investigation·E CarminaR A Lobo
Jul 26, 2003·Clinical Chemistry·David A Herold, Robert L Fitzgerald
Apr 20, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Fernand LabrieJacques Leclaire
Sep 30, 2006·American Journal of Clinical Dermatology·Christina Williams, Alison M Layton
Oct 20, 2007·Journal of the American Academy of Dermatology·Christin N CollierBoni E Elewski
Mar 11, 2008·La Presse médicale·Gwenaelle Dumont-Wallon, Brigitte Dréno
Feb 11, 2011·Anais Brasileiros De Dermatologia·Flavia Alvim Sant'Anna Addor, Sergio Schalka
Apr 27, 2011·Dermato-endocrinology·Evgenia MakrantonakiChristos Zouboulis

❮ Previous
Next ❯

Citations

Feb 7, 2019·Anais Brasileiros De Dermatologia·Edileia BagatinMarco Alexandre Dias da Rocha
Jan 4, 2020·International Journal of Dermatology·Kabir SardanaGauri Vats
May 8, 2021·Expert Review of Clinical Pharmacology·Edileia BagatinCaroline Sousa Costa

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01850095

Software Mentioned

SPSS®
TargetLynx

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.