Adult ABO-incompatible liver transplantation, using A and B donors

Xenotransplantation
U SkogsbergL Bäckman

Abstract

The longer waiting time for a liver graft in patients with blood group O makes it necessary to expand the donor pool for these patients. This applies in both urgent situations and for elective patients. We report on our experience with ABO-incompatible liver transplantation using A2 and B non-secretor donors here. Between 1996 and 2005, 12 adult blood group O recipients (seven male/five female) received ABO-incompatible cadaveric liver grafts (10 A2 donors, two B non-secretor donors). The indications were either rapid deterioration of liver function or hepatocellular cancer, in blood group O recipients, where an ABO-identical/compatible graft was not available. Mean recipient age was 54+/-8 (mean+/-SD) yr. All pre-operative CDC crossmatches were negative. The initial immunosuppression was induction therapy with antithymocyte globulin (n = 3), interleukin 2 receptor antagonists (n = 3) or anti-CD20 antibody (rituximab) (n = 1), followed by a tacrolimus-based protocol. Three patients underwent plasmapheresis post-transplantation. Baseline biopsies were taken before or immediately after reperfusion of the graft and after grafting when clinically indicated. No pre-operative plasmapheresis, immunoadsorption or splenectomies were per...Continue Reading

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Citations

Dec 17, 2010·Annals of Biomedical Engineering·Azadeh Alikhani, William J Federspiel
Jun 27, 2008·Transplantation·Valeriya ZarkhinMinnie Sarwal
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Aug 4, 2021·International Journal of Surgery Case Reports·Yoshikatsu SaitohTakashi Kamei

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