Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190 BCR -ABL transcripts

OncoTargets and Therapy
Delia DimaCiprian Tomuleasa

Abstract

Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the difficult diagnosis and clinical management of M7-AML in the context of a previous hematologic disorder of undetermined significance and associated genetic abnormalities. Probably, following the complete hematologic remission and further with induction chemotherapy plus tyrosine kinase inhibitor therapy, the clinical management of this case will be followed by a allogeneic bone marrow transplantation, the only proven therapy to improve overall survival.

Citations

Aug 9, 2019·Journal of Clinical Medicine·Valentina SasUNKNOWN Romanian-Japanese Working Group of the Romanian Society for Bone Marrow Transplantation
Sep 6, 2020·Journal of Cellular and Molecular Medicine·Patric TeodorescuCiprian Tomuleasa
Nov 5, 2019·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Apr 20, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Parisa BagheriAva Ghadiri

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Methods Mentioned

BETA
flow cytometry
biopsy

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