Adult bone marrow-derived hemangioblasts, endothelial cell progenitors, and EPCs

Current Topics in Developmental Biology
G Schatteman


Long before their existence was proven, work with blood islands pointed to the existence of hemangioblasts in the embryo, and it was widely accepted that such cells existed. In contrast, though evidence for adult hemangioblasts appeared at least as early as 1932, until quite recently, it was commonly assumed that there were no adult hemangioblasts. Over the past decade, these views have changed, and it is now generally accepted that a subset of bone marrow cells or their progeny can and do function as adult hemangioblasts. This chapter will examine the basic biology of bone marrow-derived hemangioblasts and endothelial cell progenitors (angioblasts) and the relationship of these adult cells to their embryonic counterparts. Efforts to define the endothelial cell progenitor phenotype will also be discussed, though to date, there is no consensus on the definitive adult phenotype, probably because there are multiple phenotypes and because the cells are plastic. Also examined are the putative roles of bone marrow-derived cells in vascular homeostasis and repair, including both their ability to differentiate and contribute directly to vascular repair, as well as to promote vascular growth by secreting pro-angiogenic factors. Finally,...Continue Reading


Oct 15, 1978·Klinische Wochenschrift·J HladovecJ Fabián
May 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu F GorskaiaN N Kulagins
Dec 1, 1975·Experimental and Molecular Pathology·R G GerrityC J Schwartz
Apr 1, 1992·Journal of Cellular Physiology·A UmezawaJ Hata
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LamasT Michel
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W MatthewsI R Lemischka
Jan 1, 1985·Cell and Tissue Research·I C Mackenzie, J R Bickenbach
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·H J LeuM Susani
Jan 1, 1989·Cardiovascular Research·M L SchinettiM Scarlattini
Aug 1, 1989·American Journal of Hematology·S O Sowemimo-CokerR B Francis
Jul 1, 1988·Science·G J SpangrudeI L Weissman
Dec 1, 1968·Archives of Surgery·J R MackenzieD J Tibbs
Nov 1, 1966·Angiology·M J TsapogasP L Girolami
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BregniA M Gianni
Apr 1, 1994·Journal of Vascular Surgery·S M ScottE T Ahl
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K ChoiG Keller
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K G PetersL T Williams
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·R F PereiraD J Prockop
May 1, 1995·Journal of Vascular Surgery·M H WuL R Sauvage

❮ Previous
Next ❯


Jul 9, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Nilanjana SenguptaJeffrey R Harris
Jul 17, 2008·Antioxidants & Redox Signaling·Jamie CaseLaura S Haneline
Feb 13, 2008·Journal of Cellular and Molecular Medicine·Michael E BoultonMaria B Grant
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joanna W Y HoRonnie T P Poon
Oct 7, 2006·Stem Cells·David A IngramLaura S Haneline
Oct 18, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhi ZhuJilin Yi
Jun 2, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Chen ChenYihua Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

© 2021 Meta ULC. All rights reserved