Adult cirrhotic liver explants: precancerous lesions and undetected small hepatocellular carcinomas

Gastroenterology
F MionF Berger

Abstract

Despite recent advances in imaging techniques of the liver, it remains difficult to detect small precancerous lesions or hepatocellular carcinomas (HCCs) in cirrhotic livers. The goal of this study was to determine the prevalence of undetected small HCCs in liver explants of adult cirrhotic patients undergoing liver transplantation and to evaluate the association of HCCs with hepatic lesions considered premalignant. Eighty consecutive liver explants were analyzed for the presence of macroscopically atypical nodules, which were then pathologically described as macroregenerative nodules, high-grade dysplastic nodules, areas of small liver cell dysplasia, and HCCs. The prevalence of HCC was 17.5% with a mean size of 11.6 mm. HCCs were more frequently found in men (22%) than in women (4.8%; P < 0.05) and in patients older than 50 years at the time of liver transplantation (35.7% vs. 7.7% in patients younger than 50 years; P < 0.05). The prevalence of HCCs was identical in alcoholic and viral cirrhosis. HCC nodules were significantly associated with the presence of high-grade dysplastic nodules. Small HCCs and precancerous lesions are frequently found in cirrhotic liver explants, especially in men older than 50 years. This finding s...Continue Reading

Citations

Oct 29, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J P AchkarJ Rakela
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M TaniguchiJ Rakela
Mar 11, 2005·Best Practice & Research. Clinical Gastroenterology·Masamichi Kojiro
Sep 10, 2003·Transplantation Proceedings·J González-UriarteJ Ortiz de Urbina
Dec 5, 1998·Transplantation Proceedings·C LoinazE M González
Feb 20, 2003·Journal of Hepatology·Josep M Llovet, Michel Beaugrand
Nov 19, 1997·Journal of Hepatology·J C Trinchet, M Beaugrand
Aug 1, 1997·Alimentary Pharmacology & Therapeutics·R MoreauD Lebrec
Dec 21, 2002·Alimentary Pharmacology & Therapeutics·G N IoannouD C Rockey
Jul 22, 1998·Annals of Surgery·D BartschM Rothmund
Jul 20, 2002·Current Opinion in Oncology·Caio Max S Rocha Lima, Barbara Centeno
May 1, 2002·European Journal of Gastroenterology & Hepatology·Victor de LédinghenJacques Drouillard
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·W O BechsteinP Neuhaus
Jan 4, 2008·Journal of Gastroenterology and Hepatology·Carmen C-L Wong, Irene O-L Ng
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Narci C Teoh
Sep 2, 2010·World Journal of Gastroenterology : WJG·Keiji MitaYoshitake Hayashi
Feb 7, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S QuirogaA Alvarez-Castells
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Apr 2, 2014·Nature Reviews. Gastroenterology & Hepatology·Andrea A Gossard, Keith D Lindor
Sep 18, 2014·Journal of the American Veterinary Medical Association·Catherine C CortrightHollis N Erb
Feb 20, 2009·Journal of Gastroenterology·Masatoshi Kudo
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Rodés
Jan 5, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-Y Mabrut, C Ducerf
Dec 19, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M TaboneL Capussotti
Jun 15, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luigi BolondiFabio Piscaglia
Feb 26, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Josep FusterJuan Carlos García-Valdecasas
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eugenio CaturelliMarcello Anti
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Masamichi Kojiro
Dec 5, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaaki HidakaTakashi Kanematsu
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fabio Piscaglia, Luigi Bolondi
Jul 19, 2002·Clinics in Liver Disease·Neil D TheiseMasamichi Kojiro
Jun 6, 2003·Alimentary Pharmacology & Therapeutics·M MelaA K Burroughs
Oct 12, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·D FoltysG Otto

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