Adult exposure to sasanguasaponin induces spermatogenic cell apoptosis in vivo through increased oxidative stress in male mice

Toxicology and Industrial Health
Jian LiYaoxing Chen

Abstract

Effects of sasanguasaponin (SGS), a compound from defatted seeds of Camellia oleifera, on abnormal spermatogenesis were studied in adult male mice using daily intragastric administration of 100, 200 and 400 mg/kg body weight (BW) for 6 weeks. The sperm counts decreased and the number of abnormal spermatozoa increased in mice treated with SGS at 400 mg/kg dose level. Testicular weight and seminiferous tubular area gradually decreased as dosage increased to 400 mg/kg SGS. Germ cells were rarefied and showed irregular distribution in seminiferous tubules (STs). Apoptosis was pronounced among spermatocytes and spermatids at the 400 mg/kg dose level. Antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxide capacity (T-AOC) markedly decreased and malondialdehyde (MDA) concentration increased in the testes. These results suggest that adult exposure to SGS (400 mg/kg) induces spermatogenic apoptosis through increased oxidative stress in male mice.

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A J Wyrobek, W R Bruce
Jan 1, 1969·Journal of Animal Science·R P Amann, J T Lambiase
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Mayer, M Noble
May 1, 1996·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y Sagesaka-MitaneK Kyuki
Aug 1, 1997·British Journal of Pharmacology·K TamuraH Kogo
Dec 12, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Z O Jónsson, U Hübscher
Aug 28, 1998·Science·D R Green, J C Reed
Nov 25, 1998·Medicinal Research Reviews·G W Qin, R S Xu
Apr 1, 1999·The Histochemical Journal·A A Al-Hazzaa, I D Bowen
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·V HaridasJ U Gutterman
Oct 30, 2001·International Journal of Radiation Biology·T PauneskuG E Woloschak
Feb 21, 2002·Biological & Pharmaceutical Bulletin·Jing CaiYong Ju
Mar 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Allen M Gown, Mark C Willingham
Dec 21, 2002·The British Journal of Nutrition·George FrancisKlaus Becker
Feb 5, 2003·Toxicology Letters·Il-Hwan KimBoo-Hyon Kang
May 17, 2003·Fertility and Sterility·Ashok AgarwalMohamed A Bedaiwy
Jul 17, 2003·Environmental Research·H KabutoT Shishibori
Apr 7, 2004·Journal of Biomedical Science·Parminder Kaur, Mohinder P Bansal
Apr 28, 2004·Molecular and Cellular Endocrinology·P VernetJ R Drevet
Oct 13, 2004·Free Radical Biology & Medicine·Ayelet M SamuniJames B Mitchell
Nov 17, 2004·The Journal of Biological Chemistry·Durga Prasad Mishra, Chandrima Shaha
Jul 5, 2005·Burns : Journal of the International Society for Burn Injuries·Qiren HuangYucheng Dai
Sep 27, 2005·Contraception·Claudia GiampietriPaola De Cesaris
Dec 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·A Rodríguez-HernándezJ A Sánchez-Alcázar
Mar 25, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jia ShenLijun Du

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Citations

Jul 11, 2013·International Journal of Environmental Research and Public Health·Fengyuan WangWeimin Lai
Oct 8, 2013·Toxicology and Industrial Health·Jin ChenYi Geng
Jan 17, 2020·Metabolites·Mohammed S HifnawyUsama Ramadan Abdelmohsen
Oct 12, 2021·Journal of Natural Products·Alana ShunnarahAngela I Calderón

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis