Adult Fanconi syndrome secondary to kappa-light chain myeloma: improvement of tubular functions after treatment for myeloma

Nephron
S UchidaF Marumo

Abstract

A 66-year-old man with kappa-light chain multiple myeloma had adult Fanconi syndrome. Renal tubular transport abnormalities consisted of renal tubular acidosis, renal glycosuria, aminoaciduria, phosphaturia and renal hypouricemia. After therapy for multiple myeloma, urinary Bence Jones protein became undetectable, and all these renal tubular abnormalities except urate wasting were corrected. Histological examination revealed electron-dense tubular and rod-like deposits in proximal tubular epithelium. This clinical observation suggests that the renal tubular transport defects were secondary to the myeloma process, possibly due to Bence Jones proteinuria.

Citations

Oct 1, 1995·Clinical Endocrinology·B L ClarkeL A Fitzpatrick
Feb 2, 2011·Leukemia & Lymphoma·Manisha BhutaniHani Hassoun
Jul 1, 1995·Kidney International·M LeboulleuxP Aucouturier
Oct 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew R ElliottJamie P Dwyer
Feb 13, 2009·Clinical Transplantation·S BalamuthusamyV Batuman
Jun 15, 1990·Biochemical and Biophysical Research Communications·K OhtaF Marumo
Jan 8, 2000·Hematology/oncology Clinics of North America·M Q Lacy, M A Gertz
Oct 27, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Loghman-AdhamA K Cheung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Related Papers

Journal of Clinical Pathology
R L Sewell, M S Dorreen
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
K YonemuraA Hishida
Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
T IsobeT Shinoda
© 2021 Meta ULC. All rights reserved