Adult granulosa cell tumor of the ovary: fine-needle-aspiration cytology of 10 cases and review of literature

Diagnostic Cytopathology
Sarfraz AliMomin T Siddiqui

Abstract

Adult granulosa cell tumor (GCT) of the ovary is mostly diagnosed in postmenopausal women. They typically secrete estrogen, which stimulates the endometrium to proliferate and cause abnormal bleeding. This study reviews the cytologic features of adult GCT of the ovary diagnosed by fine-needle aspiration (FNA). We reviewed slides from ten cases diagnosed by CT guided FNA from 1995 to 2007 at our institutions. Smears were stained with Diff-Quik and Papanicolaou stains. Patient's history and histologic diagnosis were also available and reviewed for all cases. The patients ranged in age from 39 to 83 yr. All 10 cases were hypercellular with both large and small overlapping cell clusters and individual cells. The cytologic features identified included: naked nuclei (10/10 cases), Call-Exner bodies (7/10 cases), blood vessels with prominent perivascular tumor cell growth (4/10 cases), spindle-shaped hyperchromatic stromal cells within cellular clusters (6/10 cases), mixed inflammation (3/10 cases), tumor cell necrosis (1/10 cases), and prominent metachromatic stroma seen in association with blood vessels (1/10 cases). Moderate to scant delicate cytoplasm was also seen (10/10 cases). Small, punctuate cytoplasmic vacuoles were also not...Continue Reading

References

Mar 12, 1987·The New England Journal of Medicine·UNKNOWN Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Dev
Aug 1, 1984·The American Journal of Surgical Pathology·R H YoungR E Scully
Apr 1, 1983·Gynecologic Oncology·G OhelJ G Schenker
Jun 1, 1981·Gynecologic Oncology·E Björkholm, C Silfverswärd
Mar 1, 1995·Gynecologic Oncology·R SegalG Thomas
Apr 17, 1993·Lancet·W WillemsenR Rolland
Feb 1, 1994·Journal of Surgical Oncology·B PiuraM Glezerman
Jan 1, 1994·Gynecologic Oncology·H MalmströmE Simonsen
May 15, 1997·Cancer·B E MillerD M Gershenson
Jan 1, 1997·Archives of Gynecology and Obstetrics·E Aboud
Jan 7, 1998·Human Pathology·R H HildebrandtT A Longacre
Oct 9, 1998·Clinical Oncology : a Journal of the Royal College of Radiologists·P SavageM E Gore
Apr 4, 2000·Archives of Pathology & Laboratory Medicine·Y L ChoiG Ahn
Nov 18, 2000·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·S SasanoS Nitta
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggage
Apr 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R J WilliamsD Prakash
Nov 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·T FujimotoS Fujimoto
Mar 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H Fox

❮ Previous
Next ❯

Citations

Sep 3, 2011·Veterinary Clinical Pathology·Thaís R FernandesNoeme S Rocha
Jan 22, 2010·Indian Journal of Pathology & Microbiology·Kalpana Azad, Jitender M Khunger
Sep 26, 2012·ISRN Obstetrics and Gynecology·Rani KanthanSelliah Kanthan
Mar 23, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M Fernández-CidA Rotili
Jun 26, 2012·Diagnostic Cytopathology·Solomon Lee, Lisa Duncan
Apr 21, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·A AhujaM K Vijay
Feb 20, 2014·Diagnostic Cytopathology·Rohit Inder SinghPaolo Gattuso
Mar 5, 2013·Diagnostic Cytopathology·Mahendra KumarPranab Dey
Jan 22, 2015·Diagnostic Cytopathology·Makiko OmoriShuji Hirata
Dec 25, 2013·International Journal of Endocrinology·Marie Lindhardt JohansenAnders Juul
Nov 10, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ziyad AlguraanEren Berber
Sep 3, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·N GuptaR Nijhawan
Jun 11, 2015·Molecular Endocrinology·Zhilin LiuJoAnne S Richards
Aug 20, 2021·Cancer Cytopathology·Liz N EdmundRajmohan Murali

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.