Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group

The Journal of Clinical Endocrinology and Metabolism
Andrea F AttanasioChristian J Strasburger

Abstract

The onset of adult GH deficiency may be during either adulthood (AO) or childhood (CO), but potential differences have not previously been examined. In this study the baseline and GH therapy (12.5 micrograms/kg per day) data from CO (n = 74; mean age 29 yr) and AO (n = 99; mean age 44 yr) GH-deficient adult patients have been compared. The first 6 months comprised randomized, double-blind treatment with GH or placebo, then all patients were GH-treated for a further 12 months. At baseline the height, body weight, body mass index, lean body mass, and waist/hip ratio of AO patients were significantly (P < 0.001) greater than in CO patients. Serum insulin-like growth factor-I (IGF-I) levels were below normal but were lower in CO than AO patients (P < 0.001), and the correlation with IGF binding protein-3 was stronger in CO than in AO patients. Osteocalcin concentration in CO patients was above the normal range and significantly greater than in AO patients. Both groups had significant psychosocial distress, but the deviation from normality was greater in AO patients. Throughout GH therapy there was a significant increase in lean body mass and significant decrease in percent body fat and sum of skinfolds in each group. Wais/hip ratio...Continue Reading

Citations

Aug 25, 2012·Pituitary·Shingo FujioKazunori Arita
Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Sep 1, 2008·Journal of Clinical Research in Pediatric Endocrinology·Merih BerberoğluIlknur Arslanoğlu
Nov 5, 1998·Journal of Endocrinological Investigation·G AimarettiE Ghigo
Jan 29, 2011·Journal of Endocrinological Investigation·M E Molitch
Apr 18, 2008·Der Internist·M Faust, C J Strasburger
Jun 16, 2015·Endocrine Journal·Akira ShimatsuKazuo Chihara
Oct 8, 2020·Reviews in Endocrine & Metabolic Disorders·Cesar Luiz Boguszewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Elena ValassiKaren K Miller
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Heidi Chamberlain Shea, Richard A Levy
Journal of Clinical Research in Pediatric Endocrinology
Mitchell E Geffner
© 2022 Meta ULC. All rights reserved