Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study

Alimentary Pharmacology & Therapeutics
Natalia MouratidouOla Olén

Abstract

Growth retardation is well described in childhood-onset inflammatory bowel disease (IBD). To study if childhood-onset IBD is associated with reduced final adult height. We identified 4201 individuals diagnosed with childhood-onset IBD 1990-2014 (Crohn's disease: n = 1640; ulcerative colitis: n = 2201 and IBD-unclassified = 360) in the Swedish National Patient Register. Patients with IBD attained a lower adult height compared to reference individuals (adjusted mean height difference [AMHD] -0.9 cm [95% CI -1.1 to -0.7]) and to their healthy siblings (AMHD -0.8 cm [-1.0 to -0.6]). Patients with Crohn's disease (CD) were slightly shorter than patients with ulcerative colitis (UC; -1.3 cm vs -0.6 cm). Lower adult height was more often seen in patients with pre-pubertal disease onset (AMHD -1.6 cm [-2.0 to -1.2]), and in patients with a more severe disease course (AMHD -1.9 cm, [-2.4 to -1.4]). Some 5.0% of CD and 4.3% of UC patients were classified as growth retarded vs 2.5% of matched reference individuals (OR 2.42 [95% CI 1.85-3.17] and 1.74 [1.36-2.22] respectively). Patients with childhood-onset IBD on average attain a slightly lower adult height than their healthy peers. Adult height was more reduced in patients with pre-puber...Continue Reading

References

Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·B S Kirschner
Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·H HildebrandB Kristiansson
Nov 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·R M IssenmanL Fraher
May 14, 1994·BMJ : British Medical Journal·A Ferguson, D M Sedgwick
May 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·B S Kirschner
May 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·J MarkowitzF Daum
Jul 1, 1993·Gut·A M GriffithsP M Sherman
Apr 29, 1998·BMJ : British Medical Journal·H T DaviesM Tavakoli
Jun 22, 2002·Gut·N AlemzadehR A van Hogezand
Jan 9, 2007·Inflammatory Bowel Diseases·Thomas D WaltersAnne M Griffiths
Sep 18, 2007·Journal of Pediatric Gastroenterology and Nutrition·Fernando A NavarroBarbara S Kirschner
Jun 9, 2009·European Journal of Epidemiology·Jonas F LudvigssonAnders Ekbom
Jun 22, 2010·Inflammatory Bowel Diseases·Eric I BenchimolAnne M Griffiths
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Dec 21, 2011·Archives of Disease in Childhood·Paula van DommelenStef van Buuren
Jun 5, 2012·Digestive Diseases and Sciences·B LambertA S Day
Jun 30, 2012·Digestive Diseases and Sciences·Neera GuptaEric Vittinghoff
Mar 6, 2013·Journal of Pediatric Gastroenterology and Nutrition·Petter MalmborgHans Hildebrand
Apr 9, 2014·Journal of Molecular Endocrinology·Bettina SederquistLars Sävendahl
Aug 5, 2014·European Journal of Gastroenterology & Hepatology·Denise HerzogUNKNOWN Swiss IBD Cohort Study Group
Apr 7, 2015·Inflammatory Bowel Diseases·Petter MalmborgHans Hildebrand
Jan 12, 2016·Inflammatory Bowel Diseases·Carl Frédéric DuchatellierDevendra K Amre
Jan 16, 2016·European Journal of Epidemiology·Jonas F LudvigssonWeimin Ye
Sep 27, 2016·The Journal of Pediatrics·Björn WettergrenJonas F Ludvigsson
Nov 1, 2016·Scandinavian Journal of Gastroenterology·Gustav L JakobssonJonas F Ludvigsson
Aug 16, 2017·The American Journal of Gastroenterology·Silvia GhioneUNKNOWN Epimad Group
Nov 16, 2018·Gastroenterology Report·Udayakumar NavaneethanRavi Kiran
Feb 1, 2019·Scandinavian Journal of Gastroenterology·Åsa H EverhovOla Olén
May 6, 2019·Journal of Epidemiology and Community Health·Emelie BenyiLars Sävendahl

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Citations

Nov 4, 2020·Biomedicines·Flavia Amaro, Francesco Chiarelli
Jul 3, 2021·Nutrients·Teresa Di ChioOsvaldo Borrelli
Jul 10, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Simon S M ChanHamed Khalili

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