Adult hypothalamic neurogenesis and sleep-wake dysfunction in aging.

Sleep
Andrey KostinMd Noor Alam

Abstract

In the mammalian brain, adult neurogenesis has been extensively studied in the hippocampal sub-granular zone and the sub-ventricular zone of the anterolateral ventricles. However, growing evidence suggests that new cells are not only "born" constitutively in the adult hypothalamus, but many of these cells also differentiate into neurons and glia and serve specific functions. The preoptic-hypothalamic area plays a central role in the regulation of many critical functions, including sleep-wakefulness and circadian rhythms. While a role for adult hippocampal neurogenesis in regulating hippocampus-dependent functions, including cognition, has been extensively studied, adult hypothalamic neurogenic process and its contributions to various hypothalamic functions, including sleep-wake regulation are just beginning to unravel. This review is aimed at providing the current understanding of the hypothalamic adult neurogenic processes and the extent to which it affects hypothalamic functions, including sleep-wake regulation. We propose that hypothalamic neurogenic processes are vital for maintaining the proper functioning of the hypothalamic sleep-wake and circadian systems in the face of regulatory challenges. Sleep-wake disturbance is a...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B Rusak, I Zucker
Nov 1, 1992·Behavioral and Neural Biology·R D BurwellM Gallagher
Nov 6, 1989·Neuroscience Letters·M C SenutY Lamour
Nov 1, 1989·Neurobiology of Aging·D J DijkR H van den Hoofdakker
Jan 1, 1985·Neuropathology and Applied Neurobiology·R R Sturrock, K A Rao
Jul 1, 1980·The Journal of Comparative Neurology·S J Wiegand, J L Price
Jan 1, 1993·Brain Research Bulletin·W WittingD F Swaab
Jan 12, 1996·Science·J E SherinC B Saper
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Aug 26, 1998·Journal of Neurobiology·J M García-VerdugoA Alvarez-Buylla
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P J ShiromaniM Thakkar
Aug 11, 2000·JAMA : the Journal of the American Medical Association·E Van CauterL Plat
Oct 31, 2000·Neuron·T C ThannickalJ M Siegel
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H GongD McGinty
Apr 3, 2001·The Journal of Comparative Neurology·U V Berger, M A Hediger
Aug 8, 2001·The European Journal of Neuroscience·A ArvidssonO Lindvall
May 29, 2002·Brain Research Bulletin·Arturo Alvarez-BuyllaFiona Doetsch
Jul 3, 2002·Nature Reviews. Neuroscience·Nicolas BertrandFrançois Guillemot
Jul 20, 2002·Physiology & Behavior·Yong-Lu HuangJiang-Ning Zhou
Jul 30, 2002·Progress in Brain Research·Jack M Parent, Daniel H Lowenstein
Sep 3, 2002·The Journal of Physiology·Natalia SuntsovaDennis McGinty
Oct 24, 2002·Neurobiology of Aging·Rafael J Salin-PascualPriyattam J Shiromani
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael A PackerGrigori Enikolopov
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christine T EkdahlOlle Lindvall
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eleni A MarkakisFred H Gage
Mar 8, 2005·Trends in Neurosciences·Clifford B SaperJoshua Gooley
Mar 10, 2005·Experimental Neurology·Yi XuChizuka Ide

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Citations

Jun 3, 2021·International Journal of Molecular Sciences·Ricardo Ceriani, Kathleen E Whitlock

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