Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay

Neuropharmacology
Laura L LocklearKarl J Fryxell

Abstract

Nicotine has both rewarding and aversive properties in rodents, as shown by intravenous self-administration, intracranial self-stimulation, and conditioned place preference experiments. However, high throughput models of nicotine reward have not been developed in mice. In previous two-bottle studies, mice often chose to drink less from the nicotine bottle than from the water bottle, which raises the question whether these paradigms provide a model of the reinforcing properties of oral nicotine. We hypothesized that previous two-bottle choice paradigms included factors (such as the brief duration of trials, the addition of flavorings to both bottles, water bottles located relatively close to each other, etc.) that may have obstructed the formation of a learned association between the taste of nicotine and its delayed pharmacological effects. Here we show that a paradigm designed to simplify the acquisition of a learned association resulted in nicotine consumption by various strains and sexes that diverged progressively over a period of seven weeks. The strain and sex with the highest nicotine consumption (C57BL/6J females) showed steady and statistically significant increases in nicotine consumption throughout this period. C57BL...Continue Reading

References

Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·D H MalinO B Wilson
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·F R GeorgeS R Goldberg
Jan 1, 1988·Psychopharmacology·R M Craft, J L Howard
Jun 1, 1983·Journal of Pharmacological Methods·P P RowellB D Bennett
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·C J MeliskaR A Jensen
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·F O Risinger, R A Oakes
Sep 1, 1994·Addictive Behaviors·J D KasselM Zettler-Segal
Apr 1, 1996·Psychopharmacology·S F RobinsonA C Collins
Jan 12, 2000·Brain Research·R IsolaM Hadjiconstantinou
Jun 1, 2000·Neuropsychobiology·R MaehlerW H Vogel
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·K Pietilä, L Ahtee
Jan 5, 2002·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·P F Sullivan, K S Kendler
Jul 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walter AdrianiGiovanni Laviola
Oct 31, 2002·Psychopharmacology·Wendy J LynchMarilyn E Carroll
Sep 13, 2003·The Journal of Pharmacology and Experimental Therapeutics·M I DamajB R Martin
Sep 19, 2003·Lancet·Majid Ezzati, Alan D Lopez
Jan 7, 2004·Nature Reviews. Neuroscience·Steven R Laviolette, Derek van der Kooy
Feb 21, 2004·BMC Genetics·Ellen L GoodeUNKNOWN Framingham Heart Study
Feb 21, 2004·BMC Genetics·Ming D LiUNKNOWN Framingham Heart Study
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Laura Cousino KleinHelen M Kamens
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joel GelernterHeping Zhang
Feb 25, 2005·Behavioral Neuroscience·Christopher M ButtJerry A Stitzel
Jun 23, 2005·Behavior Genetics·Jacqueline M VinkDorret I Boomsma
Aug 9, 2005·Biological Psychiatry·Hongwen ZhuNoboru Hiroi
Nov 4, 2006·Biological Psychiatry·Joel GelernterHenry R Kranzler
Oct 2, 2007·Frontiers in Neuroendocrinology·Jill B Becker, Ming Hu
Jun 7, 2008·Biological Psychiatry·Ming D LiRobert C Elston
Dec 17, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Alan E Boyle, Kathryn J Gill
Jan 6, 2009·Pharmacology, Biochemistry, and Behavior·Laura E O'Dell, Taline V Khroyan

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Citations

Jul 26, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Shakir D AlsharariMohamad Imad Damaj
Oct 6, 2015·Pharmacology, Biochemistry, and Behavior·Tanseli NesilSakire Pogun
Jun 1, 2016·Pharmacology, Biochemistry, and Behavior·C R KastenS L Boehm
Jun 28, 2016·Addiction Biology·Marilyn E Carroll, Wendy J Lynch
Nov 17, 2017·Alcoholism, Clinical and Experimental Research·Marcus M WeeraJulia A Chester
Oct 14, 2018·European Child & Adolescent Psychiatry·Elena RaffettiMaria Rosaria Galanti
Nov 22, 2016·Journal of Neuroscience Research·Sakire PogunLutfiye Kanit
May 7, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·E Carstens E, M Iodi Carstens

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