Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling.

Cell Stem Cell
Germán BelenguerIsabel Fariñas

Abstract

Adult stem cells (SCs) transit between the cell cycle and a poorly defined quiescent state. Single neural SCs (NSCs) with quiescent, primed-for-activation, and activated cell transcriptomes have been obtained from the subependymal zone (SEZ), but the functional regulation of these states under homeostasis is not understood. Here, we develop a multilevel strategy to analyze these NSC states with the aim to uncover signals that regulate their level of quiescence/activation. We show that transitions between states occur in vivo and that activated and primed, but not quiescent, states can be captured and studied in culture. We also show that peripherally induced inflammation promotes a transient activation of primed NSCs (pNSCs) mediated by tumor necrosis factor α (TNF-α) acting through its receptor, TNF receptor 2 (TNFR2), and a return to quiescence in a TNF receptor 1 (TNFR1)-dependent manner. Our data identify a signaling pathway promoting NSC alertness and add to the emerging concept that SCs can respond to the systemic milieu.

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References

Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christine T EkdahlOlle Lindvall
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Dec 11, 2003·Molecular and Cellular Neurosciences·Tamir Ben-HurNikolaos Grigoriadis
Jan 18, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Darius WideraChristian Kaltschmidt
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert E IosifOlle Lindvall
Sep 2, 2008·Brain : a Journal of Neurology·Stefano PluchinoGianvito Martino
Apr 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Erika PastranaFiona Doetsch
May 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susanne A WolfGerd Kempermann
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Nov 10, 2009·Nature Neuroscience·Celia Andreu-AgullóIsabel Fariñas
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
Jul 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sara L Montgomery, William J Bowers
Jul 27, 2011·PloS One·Fran SupekTomislav Šmuc
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Giovanna PontiArturo Alvarez-Buylla
May 24, 2013·Nature Reviews. Molecular Cell Biology·Tom H Cheung, Thomas A Rando
Aug 22, 2013·Stem Cells·Claudio GiachinoVerdon Taylor
Feb 1, 2014·Nature Methods·Michaela SpitzerMike Tyers
Mar 22, 2014·Seminars in Immunology·Guadalupe Sabio, Roger J Davis
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Aug 31, 2014·Brain, Behavior, and Immunity·W A Banks
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Feb 24, 2015·Cell Stem Cell·Elisa LaurentiJohn E Dick
Mar 10, 2015·Nature Methods·Daehwan KimSteven L Salzberg
Apr 19, 2015·Journal of Neuroinflammation·Svetlana ZonisVera Chesnokova
May 13, 2015·Bioinformatics·Wencke WalterMercedes Ricote
Mar 27, 2016·Differentiation; Research in Biological Diversity·Germán BelenguerIsabel Fariñas
May 15, 2016·Nucleic Acids Research·Zhicheng Ji, Hongkai Ji
May 29, 2016·Cold Spring Harbor Perspectives in Biology·Magdalena GötzDavid Petrik
Jul 16, 2016·Journal of Leukocyte Biology·Robert S Munford
Sep 21, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Zayna ChakerFiona Doetsch

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Citations

Feb 6, 2021·Cell Stem Cell·Stefano Pluchino, Alexandra M Nicaise
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Sara MancinelliMonica Fedele
May 8, 2021·Frontiers in Neuroscience·Sara Rojas-VázquezIsabel Fariñas
May 9, 2021·Stem Cells·Çağla DefteralıCarlos Vicario
Jul 17, 2021·Stem Cell Reports·Adrianne E S WatsonAnastassia Voronova

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