Adult neural stem cells: Long-term self-renewal, replenishment by the immune system, or both?

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Barbara S BeltzJeanne L Benton

Abstract

The current model of adult neurogenesis in mammals suggests that adult-born neurons are generated by stem cells that undergo long-term self-renewal, and that a lifetime supply of stem cells resides in the brain. In contrast, it has recently been demonstrated that adult-born neurons in crayfish are generated by precursors originating in the immune system. This is particularly interesting because studies done many years ago suggest that a similar mechanism might exist in rodents and humans, with bone marrow providing stem cells that can generate neurons. However, the relevance of these findings for natural mechanisms underlying adult neurogenesis in mammals is not clear, because of uncertainties at many levels. We argue here that the recent findings in crayfish send a strong signal to re-examine existing data from rodents and humans, and to design new experiments that will directly test the contributions of the immune system to adult neurogenesis in mammals.

References

Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Oct 29, 1982·Science·E R Kandel, J H Schwartz
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A Eglitis, E Mezey
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Apr 29, 1998·Current Opinion in Neurology·R C Scott, B G Neville
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·G C KopenD G Phinney
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Aug 1, 2000·Experimental Neurology·J Sanchez-RamosP R Sanberg
Aug 10, 2000·Journal of Neuroscience Research·D WoodburyI B Black
Oct 18, 2000·European Journal of Pharmacology·E Mezey, K J Chandross
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·N UchidaI L Weissman
Aug 25, 2001·Experimental Neurology·J R Sanchez-RamosP R Sanberg
Mar 28, 2002·The Journal of Cell Biology·William A Wells
May 4, 2002·Stroke; a Journal of Cerebral Circulation·David C HessJo Carothers
Aug 20, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tapas Kumar MakarSuhayl Dhib-Jalbut
Aug 24, 2002·Science·Raymond F CastroH David Shine
Oct 3, 2002·Journal of Neurobiology·Erin M GoergenBarbara S Beltz
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eva MezeyBarbara Crain
Oct 16, 1952·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A L HODGKIN, A F HUXLEY
Nov 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·James GoolsbyDavid Trisler
May 29, 2004·Science·Andrew E WurmserFred H Gage
Nov 24, 2004·Differentiation; Research in Biological Diversity·Tatiana TondreauDominique Bron
Aug 23, 2005·Journal of Neurobiology·Jeremy M Sullivan, Barbara S Beltz
Nov 23, 2006·The Journal of Comparative Neurology·Jeremy M SullivanBarbara S Beltz
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastian JessbergerJenny Hsieh
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Aug 30, 2007·Nature Neuroscience·Amar Sahay, Rene Hen
Oct 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J L BentonB S Beltz
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage

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Citations

Jan 2, 2016·Developmental and Comparative Immunology·Irene Söderhäll
Jan 8, 2016·Zoology : Analysis of Complex Systems, ZACS·Steffen Harzsch, Oliver von Bohlen Und Halbach
Oct 7, 2015·Frontiers in Neuroanatomy·Vladimir S MashanovJosé E García-Arrarás

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