Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches.

Translational Stroke Research
Yörg DillenAnnelies Bronckaers

Abstract

Adult neurogenesis in the subventricular zone is a topic of intense research, since it has vast implications for the fundamental understanding of the neurobiology of the brain and its potential to being harnessed for therapy in various neurological disorders. Investigation of adult neurogenesis has been complicated by the difficulties with characterization of neural stem cells in vivo. However, recent single-cell transcriptomic studies provide more detailed information on marker expression in neural stem cells and their neuronal lineage, which hopefully will result in a more unified discussion. Regulation of the multiple biological steps in adult neurogenesis comprises intrinsic mechanisms as well as extrinsic factors which together orchestrate the process. In this review, we describe the regulating factors and their cellular sources in the physiological condition and provide an overview of the regulating factors mediating stroke-induced stimulation of neurogenesis in the subventricular zone. While there is ongoing debate about the longevity of active post-natal neurogenesis in humans, the subventricular zone has the capacity to upregulate neurogenesis in response to ischemic stroke. Though, the stroke-induced neurogenesis in h...Continue Reading

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Citations

Jan 10, 2020·Stem Cells and Development·Tianqi TuYong Jiang
Jan 9, 2020·Cellular and Molecular Life Sciences : CMLS·Camilla MaffezziniChristoph Freyer
Mar 13, 2020·Journal of Neurochemistry·Albert K YeungMichael F Jackson
Dec 16, 2020·Neural Regeneration Research·Min WangChen Qiao
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Monika C ChongthamAnton B Tonchev
Feb 13, 2021·Frontiers in Oncology·Arnaud LombardNatacha Coppieters
Oct 30, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Cornelis J F van NoordenVashendriya V V Hira

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