Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Dilek ColakMagdalena Götz

Abstract

In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. Transplantation experiments further verified the cell-autonomous nature of this phenotype. Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis.

Citations

Sep 11, 2008·Cellular and Molecular Neurobiology·Xing-gang MaoHai-ning Zhen
Jul 31, 2013·Progress in Neurobiology·Shane V HegartyAideen M Sullivan
Apr 15, 2010·Neuron Glia Biology·Melanie JawerkaMagdalena Götz
Nov 19, 2011·Nature Protocols·Judith FischerMagdalena Götz
Jan 14, 2011·Cerebral Cortex·Philip GaughwinPatrik Brundin
May 21, 2011·Human Molecular Genetics·Wanda S LaymanDonna M Martin
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Dec 19, 2009·Stroke; a Journal of Cerebral Circulation·Jayshree SamantaJohn A Kessler
Nov 8, 2011·The Journal of Clinical Investigation·Vanja TepavčevićAnne Baron-Van Evercooren
May 23, 2009·Journal of Cell Science·Aaron K MobleyJoseph H McCarty
Apr 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Youngshik ChoeSamuel J Pleasure
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Monika S BrillMagdalena Götz
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ilias KazanisCharles ffrench-Constant
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie CrewsEliezer Masliah
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael A BonaguidiJohn A Kessler
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Muzhou WuPatrizia Casaccia
Jan 9, 2013·International Journal of Molecular Sciences·Jennifer K Sabo, Holly S Cate
Aug 18, 2012·Cellular and Molecular Life Sciences : CMLS·Giorgia Quadrato, Simone Di Giovanni
Apr 27, 2010·Nature Neuroscience·Beata JablonskaVittorio Gallo
May 22, 2013·Cellular and Molecular Life Sciences : CMLS·Fernando de CastroMaria Cristina Ortega
Jan 24, 2016·Brain Research·Deana M AppleErzsebet Kokovay
Feb 3, 2016·Frontiers in Cellular Neuroscience·Luis Federico BátizUrsula Wyneken
Mar 15, 2012·Hormones and Behavior·Kelli A DuncanColin J Saldanha
Jan 18, 2011·Molecular and Cellular Neurosciences·Therese AnderssonOla Hermanson
Jan 18, 2011·Brain Research Reviews·Oscar Gonzalez-Perez, Arturo Alvarez-Buylla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

© 2021 Meta ULC. All rights reserved