Adult neurogenesis transiently generates oxidative stress.

PloS One
Noah M WaltonMitsuyuki Matsumoto

Abstract

An increasing body of evidence suggests that alterations in neurogenesis and oxidative stress are associated with a wide variety of CNS diseases, including Alzheimer's disease, schizophrenia and Parkinson's disease, as well as routine loss of function accompanying aging. Interestingly, the association between neurogenesis and the production of reactive oxidative species (ROS) remains largely unexamined. The adult CNS harbors two regions of persistent lifelong neurogenesis: the subventricular zone and the dentate gyrus (DG). These regions contain populations of quiescent neural stem cells (NSCs) that generate mature progeny via rapidly-dividing progenitor cells. We hypothesized that the energetic demands of highly proliferative progenitors generates localized oxidative stress that contributes to ROS-mediated damage within the neuropoietic microenvironment. In vivo examination of germinal niches in adult rodents revealed increases in oxidized DNA and lipid markers, particularly in the subgranular zone (SGZ) of the dentate gyrus. To further pinpoint the cell types responsible for oxidative stress, we employed an in vitro cell culture model allowing for the synchronous terminal differentiation of primary hippocampal NSCs. Inducing ...Continue Reading

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Dec 18, 2013·Antioxidants & Redox Signaling·Joana M XavierCecília M P Rodrigues
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Methods Mentioned

BETA
dissection
Assay
PCR

Software Mentioned

Graphpad
ImageJ
Viaa7 RUO
Ingenuity Systems Pathway Analysis Software

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