Abstract
Early-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is associated with a favorable prognosis. Our aim was to evaluate the patterns of care of radiotherapy utilization in this disease and to define the relationship between treatment modality and survival. The National Cancer Database was queried for patients with stages I-II NLPHL diagnosed from 2004 to 2012. Patients were compared based on primary therapy into four categories: radiotherapy, chemotherapy, both, or neither. Covariate-adjusted and propensity score-weighted (PS) Cox proportional hazards models were used, adjusting for potential factors confounding survival. After exclusions, 1420 patients were evaluated, 571 (40%) received radiotherapy alone, 318 (22%) received chemotherapy alone, 351 (25%) received both, and 180 (13%) received neither. Younger patient age (P = 0.001), female gender (P = 0.019), and chemotherapy use (P < 0.001) were associated with decreased radiotherapy utilization. On PS, radiation alone (HR = 0.298, P < 0.001) and chemoradiotherapy (HR = 0.258, P < 0.001) were associated with improved survival compared to no upfront therapy, but the use of chemotherapy alone did not statistically differ compared to no initial therapy (HR = 0.784,...Continue Reading
References
Mar 29, 2002·Cancer·Richard B WilderJames D Cox
Aug 13, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas EngertUNKNOWN German Hodgkin's Lymphoma Study Group
Aug 12, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L NogováA Engert
Aug 12, 2005·Cancer·Andrew WirthDavid Christie
Oct 17, 2007·Blood·Holger SchulzMarcel Reiser
Jul 17, 2009·The Oncologist·Alfred Ian Lee, Ann S LaCasce
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronald C ChenPeter M Mauch
Nov 12, 2013·Blood·Ranjana H Advani, Richard T Hoppe
Feb 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ranjana H AdvaniNancy L Bartlett
Apr 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Martin T KingRichard T Hoppe
Apr 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Naamit K GerberJoachim Yahalom
Aug 5, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dennis A EichenauerAndreas Engert
Aug 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Rahul R ParikhJoachim Yahalom
Oct 21, 2017·Clinical Lymphoma, Myeloma & Leukemia·Bismarck OdeiDavid K Gaffney
Citations
Nov 5, 2019·British Journal of Haematology·Hidde L A PosthumaAvinash G Dinmohamed
Nov 30, 2018·British Journal of Haematology·Michael A SpinnerRanjana H Advani
Nov 30, 2020·Cancer Medicine·Shijie WangZhenming Fu
Apr 3, 2021·BMC Cancer·Saad AkhtarIrfan Maghfoor
May 1, 2021·Cancers·Novella PuglieseFabrizio Pane