PMID: 25765028Mar 15, 2015Paper

Adult-onset generalized autoimmune enteropathy involving small intestine and colon: report of a case and review of literature

Zhonghua bing li xue za zhi Chinese journal of pathology
Yumei LaiXueying Shi

Abstract

To investigate the clinicopathologic features of adult-onset autoimmune enteropathy (AIE). A case of adult-onset AIE was described along with a literature review. A 41-year-old male patient was admitted for intractable diarrhea for more than three months despite of any dietary restriction or anti-inflammatory therapy. Fat globule was observed by stool examination and Sudan III staining of the stool was positive. Enteroclysis showed weak movement and few plica of small intestine, while colonoscopy appeared normal. Small bowel biopsies revealed villus atrophy and increased crypt apoptotic bodies and lymphocytic infiltration in deep crypt. Although without significant surface intro-epithelial lymphocytosis, there were a large number of monocytes, lymphocytes, plasmacytes and neutrophilic granulocytes infiltrating in the lamina propria. Morphologically, the colonic mucous was similar to the small intestine although cryptitis and crypt abscess were significant in the former. Serum IgG anti-goblet cell antibody was demonstrated by indirect immunofluorescence. Other causes of diarrhea were excluded on the base of medical history, histopathology and other accessory examinations before the diagnosis of AIE was made. The patient had a co...Continue Reading

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