PMID: 22576401May 12, 2012Paper

Adult-onset Still's disease complicated by autoimmune hepatitis: successful treatment with infliximab

Internal Medicine
Kenji FujiiToshiyuki Ota

Abstract

A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adult-onset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequently methotrexate was added. However her symptoms and liver dysfunction relapsed when prednisolone was tapered to 20 mg/day. Therefore infliximab was introduced additionally and her symptoms and liver dysfunction subsided. To our knowledge, this is the first reported case of AOSD with AIH diagnosed by liver biopsy.

Citations

Nov 22, 2014·Clinical Rheumatology·Rema BisharaAlexandra Balbir-Gurman
Sep 17, 2013·Journal of Autoimmunity·Annarosa FloreaniGiorgina Mieli-Vergani
Mar 10, 2015·Frontiers of Medicine·Farhad Sahebjam, John M Vierling
May 25, 2016·Expert Review of Gastroenterology & Hepatology·Rodrigo LiberalDiego Vergani
Sep 28, 2017·Journal of Pediatric Gastroenterology and Nutrition·Natalia NedelkopoulouGiorgina Mieli-Vergani
Apr 17, 2018·Expert Review of Clinical Immunology·Stéphane Mitrovic, Bruno Fautrel
Oct 17, 2019·Frontiers in Pediatrics·Marco SciveresGiuseppe Maggiore
Oct 4, 2017·World Journal of Gastroenterology : WJG·Benedetta Terziroli Beretta-PiccoliDiego Vergani
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Feb 12, 2021·The Lancet. Gastroenterology & Hepatology·Rodrigo LiberalMichael A Heneghan
Jun 25, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Diego VerganiGiorgina Mieli-Vergani
Jan 12, 2020·La Revue de médecine interne·M FauterY Jamilloux

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Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.

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